CASE REPORT article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1585840
Primary vulval sebaceous carcinoma: rare case report and literature review
Provisionally accepted
- West China Second University Hospital, Sichuan University, Chengdu, China
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This study presents a rare case of primary vulval sebaceous carcinoma (SC) and a literature review. Sebaceous carcinoma is an aggressive skin malignancy, predominantly periocular, with extraocular cases being particularly uncommon. We detail a 50-year-old female patient diagnosed with primary vulval SC, exhibiting a 0.5 cm white lesion on her left vulva. Despite initial drug therapy, the lesion progressed to ulceration and induration. Histopathological examination confirmed SC. The patient underwent extensive local vulvectomy and sentinel lymph node biopsy, showing no evidence of metastasis. At 22 months post-surgery, the patient remained recurrence-free. A literature review identified 13 additional cases, highlighting diverse presentations and management strategies. Our findings underscore the importance of sentinel lymph node biopsy and tailored surgical approaches for early-stage disease. The study contributes to the understanding of this rare condition and may inform future management protocols.
Keywords: Vulval sebaceous carcinoma, Sentinel Lymph Node Biopsy, Extraocular sebaceous carcinoma, rare case report, literature review
Received: 01 Mar 2025; Accepted: 05 Aug 2025.
Copyright: © 2025 Pei, Xi and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiawen Zhang, West China Second University Hospital, Sichuan University, Chengdu, China
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