Wicked Problem | List of Frontiers open access articles

Original Research

Accepted on 25 Jul 2025

Total flavonoids of Dracocephalum moldavica L. alleviate cognitive impairment via TNF-α/NF-κB p65 signaling pathway in vascular dementia rats

in Ethnopharmacology

Shangjia Ma
Jianxin Jia
Li'e Wu
Kai Tian
Lu Wang
Hua Li
Jiayu Lv
Dewang Gao
Zhanjun Yang
Xia Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1640272

107 views

Correction

Accepted on 25 Jul 2025

KRAS and NRF2 drive metabolic reprogramming in pancreatic cancer cells: the influence of oxidative and nitrosatice stress

in Signaling

Valentina Rapozzi
Clara Comuzzi
Eros Di Giorgio
Luigi Xodo

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1661525

Original Research

Accepted on 25 Jul 2025

Trainability, persuasion or coercion: A study of human-dog and humanwolf interactions in early life

in Adaptation and Evolution

Gwendolyn Wirobski
Friederike Range
Laura Bonnet
Zsófia Virányi

Frontiers in Ethology

doi 10.3389/fetho.2025.1616436

Perspective

Accepted on 25 Jul 2025

A model to address healthcare gaps and poor research participation in Hispanic patients with Parkinson's disease

in Parkinson’s Disease and Aging-related Movement Disorders

M. Felice Ghilardi
Alessandro Di Rocco
Jennifer Fearday
Donna Sperlakis
Maria Lima
Nora Vanegas-Arroyave
Elisa Tatti
Marcelo Arroyave
evelyn stevens
Denise Hernandez

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1610448

116 views

Review

Accepted on 25 Jul 2025

Natural products targeting ferroptosis in cancer: molecular mechanisms and applications

in Cancer Molecular Targets and Therapeutics

Wenyuan Ma
Qiang Wang
Lanfang Guo
Xiaoli Ju

Frontiers in Oncology

doi 10.3389/fonc.2025.1588668

117 views

Original Research

Accepted on 25 Jul 2025

Blood memory CD8 T cell phenotypes in lung cancer patients predict immune checkpoint treatment responses

in Cancer Immunity and Immunotherapy

Kanxing Wu
Florian Schmidt
Ke Xin Bok
Yovita Ida Purwanti
Nicholas Tan
Daniel Carbajo
Andreas Wilm
Michael Fehlings
Daniel MacLeod
Alessandra Nardin

Frontiers in Oncology

doi 10.3389/fonc.2025.1629802

105 views

Brief Research Report

Accepted on 25 Jul 2025

Post-transplant cyclophosphamide in haploidentical stem cell transplantation: unveiling the impact of transplant conditioning intensity

in Alloimmunity and Transplantation

Umberto Pizzano
Simona Piemontese
Gabriele Facchin
Raffaella Greco
Marta Lisa Battista
Jacopo Peccatori
Renato Fanin
Fabio Ciceri
Francesca Patriarca
Maria Teresa Lupo Stanghellini

Frontiers in Immunology

doi 10.3389/fimmu.2025.1610391

Original Research

Accepted on 25 Jul 2025

Global, regional, and national burden and trends of depressive disorders among women of childbearing age from 1990 to 2021: insights from GBD 2021

in Health Psychology

Mingjie Tang
Yinghong Li
Jun Shao
Shiwei Li
Jiqin Tang
Zhaoming Chen

Frontiers in Psychology

doi 10.3389/fpsyg.2025.1594430

103 views

Review

Accepted on 25 Jul 2025

A review of the participation of DDIT4 in the tumor immune microenvironment through inhibiting PI3K-Akt/mTOR pathway

in Cancer Immunity and Immunotherapy

云姝焦
Yang Xiang

Frontiers in Oncology

doi 10.3389/fonc.2025.1595463

Original Research

Accepted on 25 Jul 2025

A sustainable approach tackling WEEE management using ontology-based DSS

in Modeling and Optimization for Decision Support

Ahmed Tarek
Francesco Laviano
Debora Fino
Francesca Rubertelli
Claudio Toscano

Frontiers in Sustainability

doi 10.3389/frsus.2025.1523114

154 views

Original Research

Accepted on 25 Jul 2025

Exploring factors shaping consumers' behaviour towards circular fashion: A Focus on Generations Y and Z

in Circular Economy

Aya Abdelmeguid
Mohamed Afy-Shararah
Konstantinos Salonitis

Frontiers in Sustainability

doi 10.3389/frsus.2025.1630453

Original Research

Accepted on 25 Jul 2025

A Brief Mindfulness Intervention Improves Electrophysiological Markers of Attention in Meditation-Naïve Individuals: the Moderating Role of Inattention Symptoms

in Mindfulness

Xiaoqian Yu
Christine Vinci
Geoffrey Potts

Frontiers in Psychology

doi 10.3389/fpsyg.2025.1629282

144 views

Mini Review

Accepted on 25 Jul 2025

Climate-Conscious Anesthesia in LMICs: Challenges and Opportunities for Sustainable

in Perioperative Medicine

Gautham Patel
Shubhkarman Kahlon

Frontiers in Anesthesiology

doi 10.3389/fanes.2025.1633998

Systematic Review

Accepted on 25 Jul 2025

A Scoping Review of Mentorship in Graduate Medical Education: A Proposed Conceptual Framework

in Healthcare Professions Education

Dima Abdelmannan
Rasha Buhumaid
Hira Salman
Wail Ba Madhaf
Hafidh AlRajaby
Nabil Zary
Shaista S Guraya

Frontiers in Medicine

doi 10.3389/fmed.2025.1616148

101 views

Original Research

Accepted on 25 Jul 2025

Apple Leaf Disease Image Recognition Based on a Modified Rime Optimization Algorithm and ConvNeXt Network

in Sustainable and Intelligent Phytoprotection

Jing Qian
Linjing Wei

Frontiers in Plant Science

doi 10.3389/fpls.2025.1626335

127 views

Case Report

Accepted on 25 Jul 2025

Trastuzumab deruxtecan for the treatment of metastatic non-small cell lung cancer harboring HER2 non-exon 19/20 mutations: A case series

in Cancer Immunity and Immunotherapy

Yan Meng
Yanping Du
Xiaolin Liu
Jue Huang
Hanhan Chen
Chunxia He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1631768

Articles

Total flavonoids of Dracocephalum moldavica L. alleviate cognitive impairment via TNF-α/NF-κB p65 signaling pathway in vascular dementia rats

KRAS and NRF2 drive metabolic reprogramming in pancreatic cancer cells: the influence of oxidative and nitrosatice stress

Trainability, persuasion or coercion: A study of human-dog and humanwolf interactions in early life

A model to address healthcare gaps and poor research participation in Hispanic patients with Parkinson's disease

Natural products targeting ferroptosis in cancer: molecular mechanisms and applications

Blood memory CD8 T cell phenotypes in lung cancer patients predict immune checkpoint treatment responses

Post-transplant cyclophosphamide in haploidentical stem cell transplantation: unveiling the impact of transplant conditioning intensity

Global, regional, and national burden and trends of depressive disorders among women of childbearing age from 1990 to 2021: insights from GBD 2021

A review of the participation of DDIT4 in the tumor immune microenvironment through inhibiting PI3K-Akt/mTOR pathway

A sustainable approach tackling WEEE management using ontology-based DSS

Exploring factors shaping consumers' behaviour towards circular fashion: A Focus on Generations Y and Z

A Brief Mindfulness Intervention Improves Electrophysiological Markers of Attention in Meditation-Naïve Individuals: the Moderating Role of Inattention Symptoms

Climate-Conscious Anesthesia in LMICs: Challenges and Opportunities for Sustainable

A Scoping Review of Mentorship in Graduate Medical Education: A Proposed Conceptual Framework

Apple Leaf Disease Image Recognition Based on a Modified Rime Optimization Algorithm and ConvNeXt Network

Trastuzumab deruxtecan for the treatment of metastatic non-small cell lung cancer harboring HER2 non-exon 19/20 mutations: A case series