Wicked Problem | List of Frontiers open access articles

Original Research

Published on 21 Aug 2025

Circular RNA hsa_Circ_0007552 inhibits lung adenocarcinoma proliferation, migration and invasion via the miR-7974/BAP1 axis

in Cancer Immunity and Immunotherapy

Yanping Lin
Rong Li
Xin Shen
Mingjin Wu
Jiadai Tang
Jiangyan Guo
Caixin Yin
Tingrong Xia
Dongqi Li
Fengdi Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634326

307 views

Perspective

Published on 21 Aug 2025

Challenges in diagnosis and treatment of long COVID

in Infectious Diseases: Pathogenesis and Therapy

Lei Gu
Jian Yue
Jing Lin
Zeyi Liu
Jian-an Huang

Frontiers in Medicine

doi 10.3389/fmed.2025.1641411

616 views

Original Research

Published on 21 Aug 2025

Early boosting of p38 MAPK signaling pathway by lycorine hydrochloride potently inhibits PRRSV proliferation in primary and established cells

in Virology

Lizhan Su
Zhening Zhang
Siqi Zhang
Jiajing He
Yaoqi Chen
Guohong Wu
Zhiying Zhang
Weisan Chen
Mingxin Zhang
Jianxin Chen

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1664973

634 views

Correction

Published on 21 Aug 2025

Correction: Expected occurrence of wildlife in US Atlantic offshore wind areas

in Marine Conservation and Sustainability

Deborah N. Brill
Jesse Cleary
Jason J. Roberts
Bryce R. O’Brien
Patrick N. Halpin

Frontiers in Marine Science

doi 10.3389/fmars.2025.1663700

407 views

Original Research

Published on 21 Aug 2025

Anti-Listeria activity of Lactococcus lactis subsp. lactis LAB3 cells entrapped in alginate beads: effects of inoculum size, alginate bead formulation, and atmosphere composition

in Food Microbiology

Yan He
Pascal Degraeve
Nadia Oulahal

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1663475

510 views

Original Research

Published on 21 Aug 2025

Antibodies against integrin αvβ6 have high diagnostic accuracy for ulcerative colitis

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Patrick Bez
Martina Scapolan
Davide Giuseppe Ribaldone
Gian Paolo Caviglia
Silvia Zago
Cristina Trucco
Simone Frara
Antonino Caruso
Marta Ascolani
Michele Campigotto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1641329

445 views

Case Report

Published on 21 Aug 2025

Case Report: Pathogenic PNPLA2 variants and nonsense-mediated mRNA decay result in an early-onset neutral lipid storage disease with myopathy

in Genetics of Common and Rare Diseases

Sara Missaglia
Eleonora Martegani
Corrado Angelini
Rita Horvath
Veronika Karcagi
Endre Pal
Daniela Tavian

Frontiers in Genetics

doi 10.3389/fgene.2025.1642442

403 views

Original Research

Published on 21 Aug 2025

Ginsenoside Rh2 repressed the progression of prostate cancer through the mitochondrial damage induced by mitophagy and ferroptosis

in Genitourinary Oncology

Zhen He
Jianxi Shi
Bing Zhu
Zhentao Tian
Zhihong Zhang
Changwen Zhang

Frontiers in Oncology

doi 10.3389/fonc.2025.1633891

363 views

Review

Published on 21 Aug 2025

Mitochondrial dysfunction in diabetic ulcers: pathophysiological mechanisms and targeted therapeutic strategies

in Molecular and Cellular Pathology

Yu Pan
Lin Chen
Yan Chen
Elizabeth Rosalind Thomas
Shiying Zhou
You Yang
Kezhi Liu
Jianming Wu
Xiang Li

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1625474

346 views

Original Research

Published on 21 Aug 2025

Analysis of six CYP450 genetic variants regarding the response to cannabidiol combined with anticonvulsant medication in mexican patients with drug-resistant epilepsy

in Pharmacogenetics and Pharmacogenomics

Iris A. Feria-Romero
Luisa Rocha
Araceli Reyes-Cuayahuitl
Iris Martínez-Juárez
Daniel San-Juan
Consuelo Escamilla-Nuñez
Sandra Orozco-Suarez

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1626054

414 views

Original Research

Published on 21 Aug 2025

Personalized porous tantalum implants crafted via 3D printing: new horizons in complex cervical-thoracic spinal fusion

in Biomaterials

Chang Chen
Huaquan Fan
Ge Chen
Zhong Li
Puquan Wang
Fuyou Wang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1625650

495 views

Original Research

Published on 21 Aug 2025

Delayed-onset hearing loss in first-grade students who previously passed the newborn hearing screening

in Pediatric Otolaryngology

Reem Elbeltagy
Waad AlObayed
Shatha Mashbri
Robina Alrasheed
Renad Albakiri
Munira Almulayfi
Rania Alkahtani

Frontiers in Pediatrics

doi 10.3389/fped.2025.1623225

338 views

Systematic Review

Published on 21 Aug 2025

Transformational leadership and its impact on educational innovation in Ecuador: a systematic review

in Leadership in Education

Kenya Roxana Román-Cortéz
Juan Tarquino Calderón Cisneros
Carlos Alcívar Trejo
María Paula Calderon Chapín

Frontiers in Education

doi 10.3389/feduc.2025.1630004

325 views

Original Research

Published on 21 Aug 2025

Outcomes of high BMI colorectal cancer patients with natural orifice specimen extraction surgery: a propensity-score matching study

in Colorectal and Proctological Surgery

Chenkai Zhang
Hao Zhang
Wenyang Li
Songtao Yu
Haonan Qi
Chunlin Wang
Ibatullin Artur
Guiyu Wang

Frontiers in Surgery

doi 10.3389/fsurg.2025.1624266

263 views

Original Research

Published on 21 Aug 2025

Daikenchuto improves methotrexate-induced chronic small intestinal mucositis by promoting angiogenesis

in Ethnopharmacology

Peilin Li
Yusuke Inoue
Daichi Sadatomi
Sachiko Mogami
Daisuke Miyamoto
Toshiyuki Adachi
Tomohiko Adachi
Akihiko Soyama
Kengo Kanetaka
Weili Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1623726

269 views

Brief Research Report

Published on 21 Aug 2025

Calorie and time-restricted feeding improves liver and kidney histopathology in streptozotocin-induced type 1 diabetic rats

in Metabolic Physiology

Indra Putra Taufani
Sri Rahmatul Laila
Sri Tasminatun
Sailent Rizki Sari Simaremare
Meity Mardiana
Jiro Hasegawa Situmorang

Frontiers in Physiology

doi 10.3389/fphys.2025.1629751

391 views

Articles

Circular RNA hsa_Circ_0007552 inhibits lung adenocarcinoma proliferation, migration and invasion via the miR-7974/BAP1 axis

Challenges in diagnosis and treatment of long COVID

Early boosting of p38 MAPK signaling pathway by lycorine hydrochloride potently inhibits PRRSV proliferation in primary and established cells

Correction: Expected occurrence of wildlife in US Atlantic offshore wind areas

Anti-Listeria activity of Lactococcus lactis subsp. lactis LAB3 cells entrapped in alginate beads: effects of inoculum size, alginate bead formulation, and atmosphere composition

Antibodies against integrin αvβ6 have high diagnostic accuracy for ulcerative colitis

Case Report: Pathogenic PNPLA2 variants and nonsense-mediated mRNA decay result in an early-onset neutral lipid storage disease with myopathy

Ginsenoside Rh2 repressed the progression of prostate cancer through the mitochondrial damage induced by mitophagy and ferroptosis

Mitochondrial dysfunction in diabetic ulcers: pathophysiological mechanisms and targeted therapeutic strategies

Analysis of six CYP450 genetic variants regarding the response to cannabidiol combined with anticonvulsant medication in mexican patients with drug-resistant epilepsy

Personalized porous tantalum implants crafted via 3D printing: new horizons in complex cervical-thoracic spinal fusion

Delayed-onset hearing loss in first-grade students who previously passed the newborn hearing screening

Transformational leadership and its impact on educational innovation in Ecuador: a systematic review

Outcomes of high BMI colorectal cancer patients with natural orifice specimen extraction surgery: a propensity-score matching study

Daikenchuto improves methotrexate-induced chronic small intestinal mucositis by promoting angiogenesis

Calorie and time-restricted feeding improves liver and kidney histopathology in streptozotocin-induced type 1 diabetic rats