Introduction
We recently read the article, “Acute Effects of Exercise Mode on Arterial Stiffness and Wave Reflection in Healthy Young Adults: A Systematic Review and Meta-Analysis” by Doris R. Pierce, Kenji Doma and Anthony S. Leicht (volume 13, 2018). This particular article was a review and meta-analysis that focused on changes in arterial stiffness and measures of pulse wave reflection in response to different exercise modalities. The aim of this commentary is to highlight, and to make note, on some of the data that was presented in their manuscript.
Increases in measures of pulse wave reflection, primarily the augmentation index (AIx), and the AIx at normalized to 75 beats per minute (AIx@75), are associated with increased cardiovascular mortality and morbidity (Weber et al., 2004). The AIx is defined as augmentation pressure expressed as a percentage of aortic pulse pressure. It is influenced by the timing and the amplitude of the forward traveling wave and the reflected wave (Wilkinson et al., 2000). Following resistance exercise there appears to be a significant impact on measures of pulse wave reflection (Fahs et al., 2009; Yoon et al., 2010; Kingsley et al., 2017; Tai et al., 2018). This is further supported by the meta-analysis of Pierce et al. (2018).
Concerns
However, while we were excited that our previous study, and data, are used in the meta-analysis by Pierce et al. (2018), we do have some concerns. Specifically, our primary concern revolves around the data taken from our article, Tai et al. (2018). In the article by Pierce et al., the data that are presented from Tai et al. (2018), specifically Figure 4, 1.1.2 Augmentation index, are incorrect. The data in reference are not the same in the article by Pierce et al. as they are in the article from Tai et al.
In our article, Tai et al., the AIx that was published was the peripheral AIx, and we did not correct it for changes in pulse pressure, the review article by Pierce et al. cited an AIx taken from Tai et al. that was not what was published. Tai et al. reported an augmentation index of 116.8 ± 4.2% at rest, and 123.2 ± 8.4%. However, Peirce et al. reported an augmentation index of 12.5 ± 6% at rest, and 19 ± 11.9% during recovery. From what we can tell, Peirce et al. calculated their own AIx, using our data and by dividing our reported AIx by augmentation pressure, but we are not certain. The correct data are such that resting AIx, corrected for pulse pressure, increased by 88.7%, while Peirce et al. reported that we had a 49.6% change.
Discussion
Overall, our concern is that our data were re-calculated, incorrectly, and then used in the meta-analysis. We were not contacted about our data, and were most upset to see it presented in an incorrect manner. We feel that re-calculating the AIx from our data was not the best way to proceed. We don't know how much these incorrect data influenced the outcome of the meta-analysis.
Statements
Author contributions
All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
1
FahsC. A.HeffernanK. S.FernhallB. (2009). Hemodynamic and vascular response to resistance exercise with L-arginine. Med. Sci. Sports Exerc.41, 773–779. 10.1249/MSS.0b013e3181909d9d
2
KingsleyJ. D.TaiY. L.MayoX.GlasgowA.MarshallE. (2017). Free-weight resistance exercise on pulse wave reflection and arterial stiffness between sexes in young, resistance-trained adults. Eur. J. Sport Sci.17, 1056–1064. 10.1080/17461391.2017.1342275
3
PierceD. R.DomaK.LeichtA. S. (2018). Acute effects of exercise mode on arterial stiffness and wave reflection in healthy young adults: a systematic review and meta-analysis. Front. Physiol. 9:73. 10.3389/fphys.2018.00073
4
TaiY. L.GerhartH.MayoX.KingsleyJ. D. (2018). Acute resistance exercise using free weights on aortic wave reflection characteristics. Clin. Physiol. Funct. Imaging38, 145–150. 10.1111/cpf.12396
5
WeberT.AuerJ.O'RourkeM. F.KvasE.LassnigE.BerentR.et al. (2004). Arterial stiffness, wave reflections, and the risk of coronary artery disease. Circulation109, 184–189. 10.1161/01.CIR.0000105767.94169.E3
6
WilkinsonI. B.MacCallumH.FlintL.CockcroftJ. R.NewbyD. E.WebbD. J. (2000). The influence of heart rate on augmentation index and central arterial pressure in humans. J. Physiol. 525 (Pt 1), 263–270. 10.1111/j.1469-7793.2000.t01-1-00263.x
7
YoonE. S.JungS. J.CheunS. K.OhY. S.KimS. H.JaeS. Y. (2010). Effects of acute resistance exercise on arterial stiffness in young men. Korean Circ. J.40, 16–22. 10.4070/kcj.2010.40.1.16
Summary
Keywords
vascular, augmentation index, arterial stiffness, pulse wave velocity, opinion
Citation
Kingsley JD and Tai YL (2019) Commentary: Acute Effects of Exercise Mode on Arterial Stiffness and Wave Reflection in Healthy Young Adults: A Systematic Review and Meta-Analysis. Front. Physiol. 10:1516. doi: 10.3389/fphys.2019.01516
Received
26 September 2019
Accepted
02 December 2019
Published
17 December 2019
Volume
10 - 2019
Edited by
Gary Iwamoto, University of Illinois at Urbana-Champaign, United States
Reviewed by
Scott Davis, Southern Methodist University, United States
Updates
Copyright
© 2019 Kingsley and Tai.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: J. Derek Kingsley jkingsle@kent.edu
This article was submitted to Exercise Physiology, a section of the journal Frontiers in Physiology
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