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Front. Bioeng. Biotechnol. | doi: 10.3389/fbioe.2019.00062

Using Bioactive Glasses for the Management of Burns: Hope or Hype?

  • 1Mashhad University of Medical Sciences, Iran
  • 2Department of Anatomy & Cell Biology, Faculty of Medicine, Mashhad university of Medical Sciences, Iran
  • 3Materials and Energy Research Center, Iran
  • 4Faculty of Medicine, Tehran University of Medical Sciences, Iran
  • 5Department Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Iran
  • 6Department of Mechanical and Aerospace Engineering, Polytechnic University of Turin, Italy

Abstract
The management of burn injuries is considered an unmet clinical need and, to date, no fully satisfactory solution exists to this problem. This study aims to explore the potential of bioactive glasses (BGs) for burn care due to the therapeutic effects of their ionic dissolution products. BGs have been studied for more than 40 years and boast a long successful history in the substitution of damaged tissues, especially bone. Considering their exceptional versatility and attractive characteristics, these synthetic materials have also recently been proposed in the treatment of soft tissue-related disorders such as skin wounds. Specifically, improving fibroblast proliferation, inducing angiogenesis, and eliciting antibacterial activity (with the additional advantage of avoiding administration of antibiotics) are all considered as key added values carried by BGs in the treatment of burn injuries. However, there are some issues that deserve careful consideration while proceeding with the research, including the selection of suitable BG compositions, appropriate forms of application (e.g., BG fibers, ointments or composite patches), as well as the procedures for reliable in vivo testing.

Keywords: Bioactive Glasses, Burns, Wound Healing, ion release, Angiogenesis

Received: 03 Feb 2019; Accepted: 07 Mar 2019.

Edited by:

Francesca Taraballi, Houston Methodist Research Institute, United States

Reviewed by:

Ahmed El-Fiqi, Dankook University, South Korea
Antonella Sola, University of Modena and Reggio Emilia, Italy  

Copyright: © 2019 Kargozar, Mozafari, Hamzehlou and Baino. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Saeid Kargozar, Mashhad University of Medical Sciences, Mashhad, Iran, kargozarsaeid@gmail.com