Hypothesis and Theory ARTICLE
SOX Transcription Factors in Endothelial Differentiation and Endothelial-Mesenchymal Transitions
- 1UCLA Department of Medicine, United States
The SRY (sex determining region Y)-box (SOX) transcription factors were first identified as critical regulators of male sex determination but are now known to play important role in vascular development and disease. SOX7, 17 and 18 are essential in endothelial differentiation and SOX2 have emerged as essential mediator of endothelial-mesenchymal transitions (EndMTs), a mechanism that enables the endothelium to contribute cells with abnormal cell differentiation to vascular disease such as calcific vasculopathy. Here we review the information on the SOX transcription factors in endothelial differentiation and EndMTs contributing to vascular calcification.
Keywords: Vascular Calcification, Sex determining region Y-box, Endothelial-mesenchymal transition, Endothelium, differentiation
Received: 31 Aug 2018;
Accepted: 07 Mar 2019.
Edited by:Dwight A. Towler, University of Texas Southwestern Medical Center, United States
Reviewed by:Cécile OURY, University of Liège, Belgium
Kathleen A. Martin, School of Medicine, Yale University, United States
Copyright: © 2019 Yao, Yao and Bostrom. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Dr. Yucheng Yao, UCLA Department of Medicine, Los Angeles, United States, firstname.lastname@example.org
Dr. Kristina I. Bostrom, UCLA Department of Medicine, Los Angeles, United States, email@example.com