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Front. Cardiovasc. Med. | doi: 10.3389/fcvm.2019.00126

Regenerative Effect of Platelet Concentrates in Oral and Craniofacial Regeneration

 Faez S. Al-Hamed1, Mohammed Mahri1, 2,  Haider Al-Waeli1,  Jesus Torres3,  Zahi Badran1, 4 and Faleh Tamimi1*
  • 1Faculty of Dentistry, McGill University, Canada
  • 2Jazan University, Saudi Arabia
  • 3Faculty of Dentistry, Complutense University of Madrid, Spain
  • 4Faculté de Chirurgie Dentaire, Université de Nantes, France

Platelet concentrates (PCs) are biological autologous products derived from the patient’s whole blood and consist mainly of supraphysiologic concentration of platelets and growth factors (GFs). These GFs have anti-inflammatory and healing enhancing properties. Overall, PCs seem to enhance bone and soft tissue healing in alveolar ridge augmentation, periodontal surgery, socket preservation, implant surgery, endodontic regeneration, sinus augmentation, bisphosphonate-related osteonecrosis of the jaw (BRONJ), osteoradionecrosis, closure of oroantral communication (OAC), and oral ulcers. On the other hand, no effect was reported gingival recession and guided tissue regeneration (GTR) procedures. Also, PCs could reduce pain and inflammatory complications in temporomandibular disorders (TMDs), oral ulcers, and extraction sockets. However, these effects have been clinically inconsistent across the literature. Differences in study designs and types of PCs used with variable concentration of platelets, growth factors, and leucocytes, as well as different application forms and techniques could explain these contradictory results. This study aims to review the clinical applications of PCs in oral and craniofacial tissue regeneration and the role of their molecular components in tissue healing.

Keywords: Platelet concentrates (PCs), PRP, PRF (platelet-rich fibrin), PRGF-Endoret, clinical applications, growth factors, platelets, Oral tissue regeneration

Received: 15 May 2019; Accepted: 12 Aug 2019.

Copyright: © 2019 Al-Hamed, Mahri, Al-Waeli, Torres, Badran and Tamimi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Faleh Tamimi, Faculty of Dentistry, McGill University, Montreal, Canada,