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Front. Endocrinol. | doi: 10.3389/fendo.2019.00590

Single Cell Sequencing of the Pineal Gland: The Next Chapter

 Steven L. Coon1,  Cong Fu2, Stephen Hartley3,  Lynne Holtzclaw4,  Joseph C. Mays5, Michael C. Kelly6,  Matthew W. Kelley7, James C. Mullikin8,  Martin F. Rath9, Luis E. Savastano10 and  David C. Klein4*
  • 1Molecular Genomics Laboratory, Office of the Scientific Director, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), United States
  • 2Laboratory of Theoretical and Computational Chemistry, Jilin University, China
  • 3Cancer Genetics and Comparative Genomics Branch (NHGRI), United States
  • 4Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), United States
  • 5Sackler Institute of Gradate Biomedical Sciences, School of Medicine, New York University, United States
  • 6Frederick National Laboratory for Cancer Research (NIH), United States
  • 7Section on Developmental Neuroscience, Laboratory of Cochlear Development, Division of Intramural Research, National Institute on Deafness and Other Communication Disorders (NIDCD), United States
  • 8National Institutes of Health Intramural Sequencing Center (NISC), United States
  • 9Department of Neuroscience, Faculty of Health Sciences, University of Copenhagen, Denmark
  • 10Department of Neurosurgery, School of Medicine, University of Michigan, United States

The analysis of pineal cell biology has undergone remarkable development as techniques have become available which allow for sequencing of the entire transcriptome and, most recently, the sequencing of the transcriptome of individual cells. It has been possible to identify at least nine distinct cell types in the pineal gland of the rat, allowing for the first time identification of the precise cells of origin and expression of transcripts. Here the current state of knowledge generated by these transcriptomic efforts is reviewed, with emphasis on the highlights insights suggested by the findings.

Keywords: Pineal, Single cell sequencing, melatonin, transcriptomics, adrenerigc, Pineal, Single cell sequencing, Melatonin, Adreneric, transcription profiling

Received: 28 Jun 2019; Accepted: 12 Aug 2019.

Edited by:

James M. Olcese, Florida State University, United States

Reviewed by:

Dragos Cretoiu, Carol Davila University of Medicine and Pharmacy, Romania
Yoav Gothilf, Tel Aviv University, Israel  

Copyright: © 2019 Coon, Fu, Hartley, Holtzclaw, Mays, Kelly, Kelley, Mullikin, Rath, Savastano and Klein. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. David C. Klein, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, United States,