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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Endocrinol. | doi: 10.3389/fendo.2019.00778

Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto’s Thyroiditis through the ROS-NF-κB-NLRP3 Pathway

Jiameng Liu1,  Chaoming Mao1*, Liyang Dong1*, Ping Kang1, Chao Ding1,  Xuefeng Wang1 and  Yichuan Xiao2
  • 1Department of Nuclear Medicine, Affiliated Hospital of Jiangsu University, China
  • 2Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine, China

The occurrence of the autoimmune thyroid disease Hashimoto’s thyroiditis (HT) has increased in recent years, and increasing evidence proven the effects of excessive iodine intake on thyroid disease. In this study, we examined the status of pyrptosis in thyroid tissues obtained from patients with HT and the effects of excessive iodine on the pyroptosis of thyroid follicular cells (TFCs) in an attempt to expound the effects of excessive iodine on HT pathological development. Our results showed that increased pyroptosis occurred in the thyroid tissues of HT patients, and an increase of ptroptosis activity in TFCs was primed by excessive iodine in vitro. The process is mediated by reactive oxygen species (ROS) and activation of the NF-κB signaling pathway. In addition, excessive iodine also induced NLRP3 inflammasome activation of TFCs, which promoted pyroptosis in TFCs. Moreover, the release of interleukin-1β (IL-1β) is closely linked with pyroptosis activation. Taken together, our results demonstrated that excessive iodine contributed to aberrant pyroptosis activation in TFCs, which could be a pivotal predisposing factor for HT development.

Keywords: Excessive iodine, Hashimoto’s thyroiditis, pyroptosis, Reactive Oxygen Species, NLRP3 inflammasome

Received: 16 Jul 2019; Accepted: 24 Oct 2019.

Copyright: © 2019 Liu, Mao, Dong, Kang, Ding, Wang and Xiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Chaoming Mao, Department of Nuclear Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China, jq1001@ujs.edu.cn
Dr. Liyang Dong, Department of Nuclear Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China, dongliyang0829@hotmail.com