This article is a commentary on:
MicroRNA dysregulation in multiple sclerosis
Craig S. Moore1,2* Omar De Faria Jr.1,3* Jack Antel1,2 Amit Bar-Or1,2 Timothy E. Kennedy1,3 Ajit Dhaunchak1,2,3- 1Department of Neurology and Neurosurgery, The Montreal Neurological Institute and Hospital, McGill University Health Centre, McGill University, Montreal, QC, Canada
- 2Neuroimmunology Unit, Montreal Neurological Institute and Hospital, McGill University Health Centre, McGill University, Montreal, QC, Canada
- 3Program in NeuroEngineering, McGill University, Montreal, QC, Canada
A commentary on
MicroRNA dysregulation in multiple sclerosis
by de Faria, O. Jr., Moore, C. S., Kennedy, T. E., Antel, J. P., Bar-Or, A., and Dhaunchak, A. S. (2013). Front. Gene. 3:311. doi: 10.3389/fgene.2012.00311
To the Editor,
In our review article entitled “MicroRNA dysregulation in multiple sclerosis” published online on January 22nd, 2013, we have made an error that we would like to correct.
We request to change the following sentences in the review article:
“Examination of Treg cells in MS (De Santis et al., 2010) has identified differential expression of 23 miRNAs compared with healthy controls. Of particular interest, miR-106b and miR-25 were among the significantly decreased miRNAs, both of which modulate TGF-β signaling (Petrocca et al., 2008).”
To
“Examination of Treg cells in MS (De Santis et al., 2010) has identified differential expression of 23 miRNAs compared with healthy controls. Of particular interest, miR-106b and miR-25 were among the significantly increased miRNAs, both of which modulate TGF-β signaling (Petrocca et al., 2008).”
We would also like to apply this change in a revised figure (Figure 1) that reflects the correct directionality of the altered miRNA expression in Treg cells in MS.
FIGURE 1
Figure 1. MicroRNA (miRNA) dysregulation in CNS lesions and immune cells of MS patients. miRNAs that are up- (red) and down-regulated (blue) in CNS lesions, NAWM, or immune system of MS patients have been assigned to specific cell types. Dysregulation is associated with astrocytes and oligodendrocytes in the CNS and naïve T cells, memory T cells, Th17 cells, Treg cells, and B cells in the immune system. Note that while in most cases miRNA dysregulation has been specifically detected in the mentioned cell types, miRNAs that are here assigned to oligodendrocytes, were done so exclusively on the basis of their relevance to normal oligodendrocyte biology.
We apologize to the readers of Frontiers in Genetics and to the authors of the De Santis et al., manuscript, for this error that was not corrected during the review process of our manuscript.
References
De Santis, G., Ferracin, M., Biondani, A., Caniatti, L., RosariaTola, M., Castellazzi, M., et al. (2010). Altered miRNA expression in T regulatory cells in course of multiple sclerosis. J. Neuroimmunol. 226, 165–171.
Citation: Moore CS, De Faria O Jr., Antel J, Bar-Or A, Kennedy TE and Dhaunchak A (2013) Erratum: microRNA dysregulation in multiple sclerosis. Front. Genet. 4:90. doi: 10.3389/fgene.2013.00090
Received: 01 May 2013; Accepted: 02 May 2013;
Published online: 21 May 2013.
Edited by:
Peng Jin, Emory University School of Medicine, USAReviewed by:
Peng Jin, Emory University School of Medicine, USACopyright © 2013 Moore, De Faria, Antel, Bar-Or, Kennedy and Dhaunchak. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
*Correspondence: craig.moore@mcgill.ca; omar.defaria@mail.mcgill.ca