Corrigendum: Progesterone, cerclage, pessary, or acetylsalicylic acid for prevention of preterm birth in singleton and multifetal pregnancies - A systematic review and meta-analyses

In the published article, there was an error. The results of the meta-analyses have marginally changed after exclusion of an article [Cetingoz et al., 2011] (1) that has been retracted and was included in several meta-analyses. We observed a retraction note for this article that was published in Archives of Gynecology and Obstetrics: Cetingoz et al. (2024) (2). The scientific conclusions of our systematic review will not be changed.

A correction has been made to Abstract, Results, paragraph 2. This sentence previously stated:

“Singleton pregnancies: Progesterone compared with placebo, reduced the risk of preterm birth <37 weeks 26.8% vs. 30.2% (Risk Ratio [RR] 0.82 [95% Confidence Interval [CI] 0.71 to 0.95]) (high certainty of evidence, 14 trials) thereby reducing neonatal mortality and respiratory distress syndrome.”

The corrected sentence appears below:

“Singleton pregnancies: Progesterone compared with placebo, reduced the risk of preterm birth <37 weeks 26.7% vs. 30.3% [risk ratio (RR) 0.82 (95% confidence interval [CI] 0.71–0.96)] (high certainty of evidence, 13 trials) thereby reducing neonatal mortality and respiratory distress syndrome.”

A correction has been made to Results, Effect of intervention in singleton pregnancies, Progesterone, Preterm birth across gestational weeks, paragraph 1.

This sentence previously stated:

“Low risk of bias trials showed an overall effect of progesterone to reduce the risk of preterm birth (Table 2 and Figure 2A). A reduction of any preterm birth was demonstrated for <37 gestational weeks (26.8% vs. 30.2%, RR 0.82; 95% CI 0.71 to 0.95) and <34 gestational weeks (11.7% vs. 15.2%, RR 0.78; 95% CI 0.68 to 0.89) for any administration route (high certainty of evidence).”

The corrected sentence appears below:

“Low risk of bias trials showed an overall effect of progesterone to reduce the risk of preterm birth (Table 2 and Figure 2A). A reduction of any preterm birth was demonstrated for <37 gestational weeks (26.7% vs. 30.3%, RR 0.82; 95% CI 0.71–0.96) and <34 gestational weeks (11.8% vs. 15.4%, RR 0.78; 95% CI 0.67–0.89) for any administration route (high certainty of evidence).”

A correction has been made to Results, Effect of intervention in multifetal pregnancies, Progesterone, Preterm birth across gestational weeks, paragraph 1. This sentence previously stated:

“Low risk of bias trials demonstrated no effect of progesterone (any administration route) on the risk of any preterm birth <37 gestational weeks (58.3% vs. 57.2%, RR 1.01; 95% CI 0.95 to 1.08) (moderate certainty of evidence), and <34 gestational weeks (22.4% vs. 21.6%, RR 1.02; 95% CI 0.92 to 1.12) (high certainty of evidence), neither on <35, <32, <28 gestational weeks (high certainty of evidence), nor on the risk of spontaneous preterm birth (low to moderate certainty of evidence).”

The corrected sentence appears below:

“Low risk of bias trials demonstrated no effect of progesterone (any administration route) on the risk of any preterm birth <37 gestational weeks (58.5% vs. 56.6%, RR 1.03; 95% CI 0.97–1.08; moderate certainty of evidence), and <34 gestational weeks (22.8% vs. 21.5%, RR 1.02; 95% CI 0.93–1.13; high certainty of evidence), neither on <35, <32, <28 gestational weeks (high certainty of evidence), nor on the risk of spontaneous preterm birth (low to moderate certainty of evidence).”

A correction has been made to the Supplementary material, the supplementary figures have been corrected. The corrected files are listed below:

• Appendix 5.1: SFigure 1, SFigure 5, SFigure 7, and SFigures 28-33.

• Appendix 6.1: SFigure 1, SFigure 5, and SFigure 7.

A correction has been made to the References. A note has been added next to reference 47 that it was not included when updating the Results.

The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Statements

Summary

Keywords

preterm birth, perinatal morbidity and mortality, progesterone, cerclage, pessary, acetylsalicylic acid, systematic review

Citation

Wennerholm U-B, Bergman L, Kuusela P, Ljungström E, Möller AC, Hongslo Vala C, Ekelund A-C, Liljegren A, Petzold M, Sjögren P, Svensson M, Strandell A and Jacobsson B (2025) Corrigendum: Progesterone, cerclage, pessary, or acetylsalicylic acid for prevention of preterm birth in singleton and multifetal pregnancies - A systematic review and meta-analyses. Front. Med. 12:1561413. doi: 10.3389/fmed.2025.1561413

Received

15 January 2025

Accepted

27 January 2025

Published

14 February 2025

Volume

12 - 2025

Edited and reviewed by

Natasha Hezelgrave, King's College London, United Kingdom

Updates

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Copyright

© 2025 Wennerholm, Bergman, Kuusela, Ljungström, Möller, Hongslo Vala, Ekelund, Liljegren, Petzold, Sjögren, Svensson, Strandell and Jacobsson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Bo Jacobsson bo.jacobsson@obgyn.gu.se

†These authors share first authorship

‡These authors share last authorship

Disclaimer

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