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Front. Behav. Neurosci. | doi: 10.3389/fnbeh.2018.00319

Resting-state Default Mode Network Related Functional Connectivity is Associated with Sustained Attention Deficits in Schizophrenia and Obsessive-compulsive Disorder

Jie Fan1, Jun Gan1, Wanting Liu1, Mingtian Zhong2, Haiyan Liao1, Hongchun Zhang1,  Jinyao Yi1,  Raymond C. Chan3, Changlian Tan1 and  Xiongzhao Zhu1*
  • 1Central South University, China
  • 2South China Normal University, China
  • 3Chinese Academy of Sciences, China

Background: Previous studies have indicated the resting-state default mode network (DMN) related connectivity serving as predictor of sustained attention performance in healthy people. Interestingly, sustained attention deficits as well as DMN-involved functional connectivity (FC) alterations are common in both patients with schizophrenia (SCZ) and with obsessive-compulsive disorder (OCD). Thus, the present study was designed to investigate whether the DMN related resting-state connectivity alterations in these two psychiatric disorders were neural correlates of their sustained attention impairments.
Methods: The study included 17 SCZ patients, 35 OCD patients and 36 healthy controls (HCs). Sustained attention to response task was adopted to assess the sustained attention. Resting-state scan was administrated and seed-based whole-brain FC analyses were performed with seeds located in classical DMN regions including bilateral medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC).
Results: Both SCZ and OCD patients had poorer sustained attention than HCs. Sustained attention deficits in OCD was negatively correlated with their impaired FC of right mPFC-left superior frontal gyrus (SFG) within DMN, and that in SCZ was significantly correlated with their altered FC of left mPFC-bilateral anterior cingulate cortex (ACC) which indicated interaction between DMN and salience network. In addition, the FC between left mPFC and right parietal lobe indicating the interaction between DMN and frontal-parietal network was correlated with sustained attention in both SCZ and OCD.
Conclusions: These findings suggest the importance of DMN-involved connectivity, both within and between networks in underlying sustained attention deficits in OCD and SCZ. Results further support the potential of resting-state FC in complementing information for cognitive deficits in psychiatric disorders.

Keywords: sustained attention, sustained attention to response task, Resting-state functional connectivity, Default Mode Network, salience network, Frontal-parietal network

Received: 13 Jul 2018; Accepted: 05 Dec 2018.

Edited by:

Pietro Pietrini, IMT School for Advanced Studies Lucca, Italy

Reviewed by:

Qiang Luo, Fudan University, China
Zhen Wang, Shanghai Mental Health Center (SMHC), China  

Copyright: © 2018 Fan, Gan, Liu, Zhong, Liao, Zhang, Yi, Chan, Tan and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Xiongzhao Zhu, Central South University, Changsha, China, xiongzhaozhu@csu.edu.cn