Original Research ARTICLE
Vitamin B12 levels in methamphetamine addicts
- 1Anhui Province Veterans Hospital, China
- 2Compulsory Isolated Drug Rehabilitation Center, China
- 3Department of Psychiatry, China
Object: It has been established that reduced vitamin B12 serum levels are associated with cognitive decline and mental illness. The chronic use of methamphetamine (MA), which is a highly addictive drug, can induce cognitive impairment and psychopathological symptoms. There are few studies addressing the association of MA with vitamin B12 serum levels. This study examined whether the serum levels of B12 are associated with MA addiction. Methods: serum vitamin B12, homocysteine (Hcy), glucose and triglyceride concentrations were measured in 123 MA addicts and 108 controls. In addition, data were collected on their age, marital status, level of education and Body Mass Index (BMI) for all participants. In the patient group, the data for each subject were collected using the Fagerstrom Test for Nicotine Dependence (FTND), the Alcohol Use Disorders Identification Test (AUDIT), and a drug use history, which included the age of onset, total duration of MA use, the number of relapses and addiction severity. Results: Our results showed that MA addicts had lower vitamin B12 levels (p < 0.05) than those of healthy controls, but Hcy levels were not significantly different between the two groups (p >0.05). Serum B12 levels were negatively correlated with the number of relapses in the MA group. Furthermore, binary logistics regression analysis indicated that the B12 was an influencing factor contributing to addiction severity. Conclusion: The findings of this study suggest that some MA addicts might have vitamin B12 deficiency, and serum B12 levels may be involved in the prognosis of MA addiction.
Keywords: Methamphetamine, Addiction, Vitamin B12, Homocysteine, Neurotoxicity
Received: 25 Aug 2018;
Accepted: 05 Dec 2018.
Edited by:Carlos Tomaz, Universidade Ceuma, Brazil
Reviewed by:Dennis Qing Wang, Zhujiang hospital, Southern Medical University, China
Abbas Haghparast, Shahid Beheshti University of Medical Sciences, Iran
Copyright: © 2018 Zhai, Cui, Cheng, Ao, Zhao, Wu, Shao, Ge, Song, Qi, Ling, Ma, Xu and Jiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prof. Dongliang Jiao, Department of Psychiatry, Bengbu, Anhui Province, China, firstname.lastname@example.org