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This article is part of the Research Topic

Social Decision-Making in Animals

Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Behav. Neurosci. | doi: 10.3389/fnbeh.2019.00063

Differential effects of novel dopamine reuptake inhibitors on interference with long-term social memory in mice

  • 1Institut für Biochemie und Zellbiologie, Medizinische Fakultät, Universitätsklinikum Magdeburg, Germany
  • 2Department of Pharmaceutical Chemistry, University of Vienna, Austria
  • 3Division of Molecular Biology, Biocenter, Medical University of Innsbruck, Austria
  • 4Department of Neuroproteomics, Paracelsus Medizinische Privatuniversität, Salzburg, Austria

In the laboratory, long-term social recognition memory in mice is highly susceptible to proactive and retroactive interference. Here we investigate the ability of novel designed dopamine re-uptake inhibitors (rac-CE-123 and S-CE-123) to block retroactive and proactive interference respectively. Our data shows that administration of rac-CE-123 30 min before learning blocks retroactive interference that has been experimentally induced at 3 h, but not at 6 h, post learning. In contrast S-CE-123 treatment 30 min before learning blocked the induction of retroactive interference at 6 h, but not 3 h, post learning. Administration of S-CE-123 failed to interfere with proactive interference at both 3 h and 6 h. Analysis of additional behavioral parameters collected during the memory task imply that the effects of the new dopamine re-uptake inhibitors on retroactive and proactive interference cannot easily be explained by non-specific effects on the animals’ general social behavior. Furthermore, we assessed the mechanisms of action of drugs using intracerebral in vivo-microdialysis technique. The results revealed that administration of rac-CE-123 and S-CE-123 dose dependently increased dopamine release within the nucleus accumbens of freely behaving mice. Thus, the data from the present study suggests that the dopamine re-uptake inhibitors tested protect the consolidation of long-term social memory against interference for defined durations after learning. In addition, the data implies that dopamine signaling in distinct brain areas including the nucleus accumbens is involved in the consolidation of social recognition memory in laboratory mice.

Keywords: cognitive enhancement, retroactive interference, Aggression, recognition memory, social interaction, Long-term memory, Dopamine reuptake inhibitor

Received: 28 Aug 2018; Accepted: 13 Mar 2019.

Edited by:

James P. Curley, University of Texas at Austin, United States

Reviewed by:

Sukwon Lee, Korea Brain Research Institute, South Korea
Regis Parmentier, Centre National de la Recherche Scientifique (CNRS), France  

Copyright: © 2019 Camats-Perna, Kalaba, Ebner, Sartori, Vuyyuru, Aher, Dragačević, Singewald, Engelmann and Lubec. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Mario Engelmann, Medizinische Fakultät, Universitätsklinikum Magdeburg, Institut für Biochemie und Zellbiologie, Magdeburg, Saxony-Anhalt, Germany, mario.engelmann@medizin.uni-magdeburg.de