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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2018.00626

Is Diffusion Tensor Imaging a good biomarker for early Parkinson’s Disease?

  • 1Universidade Estadual de Campinas, Brazil

Objectives: To assess white matter abnormalities in Parkinson's disease (PD).
Methods: A hundred and thirty-two patients with PD (mean age 60.93 years; average disease duration 7.8 years) and 137 healthy controls (HC; mean age 57.8 years) underwent the same MRI protocol. Patients were assessed by clinical scales and a complete neurological evaluation. We performed a TBSS analysis to compare patients and controls, and we divided patients into early PD, moderate PD, and severe PD and performed an ROI analysis using tractography.
Results: With TBSS we found lower FA in patients in corpus callosum, internal and external capsule, corona radiata, thalamic radiation, sagittal stratum, cingulum and superior longitudinal fasciculus. Increased AD was found in the corpus callosum, fornix, corticospinal tract, superior cerebellar peduncle, cerebral peduncle, internal and external capsules, corona radiata, thalamic radiation and sagittal stratum and increased RD were seen in the corpus callosum, internal and external capsules, corona radiata, sagittal stratum, fornix, and cingulum. Regarding the ROIs, a GLM analysis showed abnormalities in all tracts, mainly in the severe group, when compared to HC, mild PD and moderate PD.
Conclusions: Since major abnormalities were found in the severe PD group, we believe DTI analysis might not be the best tool to assess early alterations in PD, and probably, functional and other structural analysis might suit this purpose better. However it can be used to differentiate disease stages, and as a surrogate marker to assess disease progression, being an important measure that could be used in clinical​ trials. 

Keywords: Parkinson's disease, Movement Disorders, Neuroimaging, Diffusion Tensor Imaging, Magnetic Resonance Imaging

Received: 23 Feb 2018; Accepted: 10 Jul 2018.

Edited by:

Christian Gaser, Friedrich-Schiller-Universität Jena, Germany

Reviewed by:

Ronald Peeters, University Hospitals Leuven, Belgium
Karl Egger, Universitätsklinikum Freiburg, Germany  

Copyright: © 2018 Guimarães, Campos, Rezende, Piovesana, Azevedo, Amato Filho, Cendes and D'Abreu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mrs. Rachel P. Guimarães, Universidade Estadual de Campinas, Campinas, Brazil, rachelrpg@gmail.com