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Front. Neurol. | doi: 10.3389/fneur.2018.00904

Elevated soluble Fas and FasL in cerebrospinal fluid and serum of patients with anti-N-methyl-D-aspartate receptor encephalitis

 Yuewen Ding1, 2, Suyue Pan1, 2,  Wei Xie2*,  Hai-Ying Shen3* and  Honghao Wang1, 2*
  • 1Department of Neurology, Nanfang Hospital, Southern Medical University, China
  • 2Department of traditional Chinese medicine, Nanfang Hospital, Southern Medical University, China
  • 3Department of Neurobiology, Legacy Research Institute, United States

Objective: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune disorder that mainly affects children and young women. The Fas system contains both membrane-bound versions of Fas (mFas) and Fas ligand (mFasL), and soluble versions (sFas and sFasL), which play important roles in apoptosis and regulation of the immune system. Both the levels of sFas and sFasL and the role they play in anti-NMDAR disease pathogenesis remain unclear.
Methods: Forty-eight pairs of cerebrospinal fluid (CSF) and serum were collected from patients with anti-NMDAR encephalitis, encephalitis of other causes or peripheral neuropathy. The CSF and serum concentrations of sFas and sFasL were determined with enzyme-linked immunosorbent assay.
Results: CSF concentrations of sFas and sFasL were both incresased in anti-NMDAR encephalitis patients compared with controls patients. Serum sFas levels were also elevated in anti-NMDAR encephalitis patients relative to controls. sFas and sFasL concentrations in CSF positively correlated with the modified Rankin scale (mRS) both at onset and 6-month follow-up.
Conclusion: CSF sFas and sFasL levels were elevated in anti-NMDAR encephalitis patients, and reflect the disease severity of anti-NMDAR encephalitis.

Keywords: Anti-N-Methyl-D-Aspartate Receptor Encephalitis, soluble Fas, Soluble Fas ligand, Modified Rankin scale, Cerebrospinal Fluid

Received: 10 Jun 2018; Accepted: 05 Oct 2018.

Edited by:

Fabienne Brilot, University of Sydney, Australia

Reviewed by:

Anna Fogdell-Hahn, Karolinska Institutet (KI), Sweden
David Brown, Westmead Institute for Medical Research, Australia  

Copyright: © 2018 Ding, Pan, Xie, Shen and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
MD, PhD. Wei Xie, Nanfang Hospital, Southern Medical University, Department of traditional Chinese medicine, Guangzhou, China, xieweizn@fimmu.com
MD, PhD. Hai-Ying Shen, Legacy Research Institute, Department of Neurobiology, Portland, United States, hshen@downeurobiology.org
MD, PhD. Honghao Wang, Nanfang Hospital, Southern Medical University, Department of Neurology, Guangzhou, China, wang_whh@163.com