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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2018.00950

Regular Exercise Modify Histopathological Outcomes of Pharmacological Treatment in Experimental Autoimmune Encephalomyelitis

  • 1Universidade Estadual de Campinas, Brazil

Background: Although it has been suggested that healthier lifestyle may optimize effects of the immunomodulation drugs for treating multiple sclerosis (MS), the knowledge regarding this kind of interactions is limited.

Objective: The aim of the present study was to investigate the effects of treadmill exercise in combination with pharmacological treatment in an animal model for MS.

Methods: C57BL/6J female mice were subjected to daily treadmill exercise for 4 weeks before immunization and 6 weeks before clinical presentation of disease. Dimethyl fumarate (DMF) or glatiramer acetate (GA) were administered after the first clinical relapse. Histopathological analyses were carried out in the lumbar spinal cord at peak disease and at 1 or 14 days post-treatment (dpt).

Results: Exercised-GA treated animals demonstrated decreased astrocytic response in the spinal dorsal horn with an improvement in the paw print pressure. Exercised-DMF treated animals showed an increased microglial/macrophage response on both ventral and dorsal horn that were associated with clinical improvement and synaptic motoneuron inputs density.

Conclusion: The present data suggest that prior regular exercise can modify the effects of pharmacological treatment administered after the first relapse in a murine model for MS.

Keywords: Experimental autoimmue encephalomyelitis model, treadmill exercise, disease modifying therapies, glatiramer acetate, Dimethyl fumarate (DMF)

Received: 06 Aug 2018; Accepted: 24 Oct 2018.

Edited by:

Jorge Matias-Guiu, Complutense University of Madrid, Spain

Reviewed by:

Jorge Tolivia, Universidad de Oviedo, Spain
Maria C. Cano-Abad, Universidad Autónoma de Madrid, Spain
Ofira Einstein, Ariel University, Israel  

Copyright: © 2018 Bernardes and Oliveira. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Alexandre L. Oliveira, Universidade Estadual de Campinas, Campinas, 13083-970, São Paulo, Brazil, alroliv@unicamp.br