Case Report ARTICLE
Familial hemiplegic migraine type 3 (FHM3) with an SCN1A mutation in a Chinese family: A case report
- 1Department of Neurology, First Hospital of Jilin University, China
Familial hemiplegic migraine (FHM) is a rare, monogenic, autosomal dominant subtype of migraine, in which three genes, CACNA1A, ATP1A2, and SCN1A, are currently known to be involved. Seldom, the familial hemiplegic migraine type 3 (FHM3) is caused by mutations in SCN1A. Here, we report a rare case of an SCN1A mutation leading to FHM3 in a Chinese family. This case report describes a 62-year-old female patient was admitted to our clinic. She presented with recurrent attacks of hemiplegic migraine. Her symptoms were first suspicious of a transient ischemic attack (TIA), but they were eventually diagnosed as FHM with a c.4495T>C mutation being found in the SCN1A gene. This case highlights that when a patient presents at the clinic with TIA symptoms associated with migraine, the diagnosis of an FHM should be considered and a genetic test is indicated. The identification of SCN1A gene mutations may help us to further understand the FHM pathophysiology.
Keywords: Migraine, auras, transient ischemic attack, SCN1A mutation, Familial hemiplegic migraine type 3
Received: 28 Aug 2018;
Accepted: 29 Oct 2018.
Edited by:Filippo M. Santorelli, Fondazione Stella Maris (IRCCS), Italy
Reviewed by:Aynur Özge, Mersin University, Turkey
Sabina Cevoli, Università degli Studi di Bologna, Italy
Copyright: © 2018 Meng, Shao, Zhang, Wang, Zhang and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dr. Hong-Mei Meng, Department of Neurology, First Hospital of Jilin University, Changchun, China, firstname.lastname@example.org