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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2018.01075

CSF-Progranulin and Neurofilament light chain levels in patients with radiologically isolated syndrome - sign of inflammation

 Marc Pawlitzki1, 2*,  Catherine M. Sweeney-Reed1,  Daniel Bittner1, Anke Lux3*, Stefan Vielhaber1,  Stefanie Schreiber1,  Friedemann Paul4, 5, 6 and Jens Neumann1
  • 1Universitätsklinik für Neurologie, Otto-von-Guericke-Universität Magdeburg, Germany
  • 2Institut für Translationale Neurologie, Universitätsklinikum Münster, Germany
  • 3Medizinische Fakultät, Universitätsklinikum Magdeburg, Germany
  • 4Charité Universitätsmedizin Berlin, Germany
  • 5NeuroCure, Charité Universitätsmedizin Berlin, Germany
  • 6Max-Delbrück-Centrum für Molekulare Medizin, Helmholtz-Gemeinschaft Deutscher Forschungszentren (HZ), Germany

Background: Cerebrospinal fluid (CSF) markers of disease in patients with radiologically isolated syndrome (RIS) are the subject of intense investigation, because they have the potential to enhance our understanding of the natural disease course and provide insights into similarities and differences between RIS and other multiple sclerosis (MS) disease identities.
Methods: Here we compared neurofilament light chain (NFL) and progranulin (PGRN) levels in the CSF in RIS patients with levels in patients with different subtypes of MS and healthy controls (HC) using Kruskal–Wallis one-way analysis of variance.
Results: Median CSF NFL concentrations in RIS patients did not differ to those in HC and clinically isolated syndrome (CIS) patients, but were significantly lower than in relapsing remitting (RRMS) and primary progressive (PPMS) MS patients. In contrast, RIS patients exhibited higher median CSF PGRN levels than HC and showed no significant differences compared with CIS, RRMS, and PPMS cases.
Conclusion: We postulate that elevated PGRN values in the CSF of RIS patients might indicate inflammatory and repair activity prior to axonal disintegration.

Keywords: Cerebrospinal Fluid – CSF, Progranulin (PGRN), Neurofilament light chain (NFL), Inflammation, Multiple Sclerois and Neuroimmunology

Received: 18 Oct 2018; Accepted: 26 Nov 2018.

Edited by:

Jorge Matias-Guiu, Complutense University of Madrid, Spain

Reviewed by:

Angel P. Sempere, Hospital General Universitario de Alicante, Spain
Julián Benito León, Hospital Universitario 12 De Octubre, Spain  

Copyright: © 2018 Pawlitzki, Sweeney-Reed, Bittner, Lux, Vielhaber, Schreiber, Paul and Neumann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
MD. Marc Pawlitzki, Universitätsklinik für Neurologie, Otto-von-Guericke-Universität Magdeburg, Magdeburg, 39120, Saxony-Anhalt, Germany,
Dr. Anke Lux, Medizinische Fakultät, Universitätsklinikum Magdeburg, Magdeburg, Saxony-Anhalt, Germany,