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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2018.01090

Cerebrospinal fluid pressure-related features in chronic headache: a prospective study and potential diagnostic implications

 Francesco Bono1*, Maria Curcio1,  Laura Rapisarda1, Basilio Vescio2, Caterina Bombardieri1, Domenica Mangialavori3, Umberto Aguglia1 and  Aldo Quattrone4
  • 1Dipartimento di Scienze Mediche e Chirurgiche, Università degli Studi Magna Graecia, Italy
  • 2Biotecnomed, Italy
  • 3Istituto di Oftalmologia, Dipartimento di Scienze mediche, chirurgiche e neuroscienze, Università della Magna Grecia, Italy
  • 4Istituto di Bioimmagini e Fisiologia Molecolare (IBFM), Italy

Objective: To identify the pressure-related features of isolated cerebrospinal fluid hypertension (ICH) in order to differentiate headache sufferers with ICH from those with primary headache disorder.
Methods: In this prospective study, patients with refractory chronic headaches and suspected of having cerebrospinal fluid-pressure elevation without papilledema or sixth nerve palsy, together with controls underwent 1-hour lumbar cerebrospinal fluid pressure monitoring via a spinal puncture needle.
Results: We recruited 148 consecutive headache patients and 16 controls. Lumbar cerebrospinal fluid pressure monitoring showed high pressure and abnormal pressure pulsations in 93 (63 %) patients with headache: 37 of these patients with the most abnormal pressure parameters (opening pressure above 250 mm H2O, mean pressure 301 mm H2O, mean peak pressure 398 mm H2O, and severe abnormal pressure pulsations) had the most severe headaches and associated symptoms (nocturnal headache, postural headache, transient visual obscuration); 56 patients with the less abnormal pressure parameters (opening pressure between 200 and 250 mm H2O, mean pressure 228 mm H2O, mean peak pressure 316 mm H2O, and abnormal pressure pulsations) had less severe headaches and associated symptoms.
Conclusions: Nocturnal and postural headache, and abnormal pressure pulsations are the more common pressure-related features of ICH in patients with chronic headache. Abnormal pressure pulsations may be considered a marker of ICH in chronic headache.

Keywords: isolated CSF hypertension, Idiopathic Intracranial Hypertension, one-hour lumbar CSF pressure monitoring via a spinal puncture needle, high CSF pressure, abnormal CSF pressure pulsation

Received: 17 Aug 2018; Accepted: 28 Nov 2018.

Edited by:

Massimiliano Valeriani, Bambino Gesù Children Hospital (IRCCS), Italy

Reviewed by:

Stephanie J. Nahas, Thomas Jefferson University, United States
Andreas Gantenbein, RehaClinic, Switzerland  

Copyright: © 2018 Bono, Curcio, Rapisarda, Vescio, Bombardieri, Mangialavori, Aguglia and Quattrone. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Francesco Bono, Dipartimento di Scienze Mediche e Chirurgiche, Università degli Studi Magna Graecia, Catanzaro, Italy, f.bono@unicz.it