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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2018.01093

Outcome Prediction by 40-Hz Steady-State Response after Large Hemispheric Infarction

Yao Wang1,  Kaibin Huang1, Shengnan Wang1, Honghao Wang1, Zhong Ji1,  Suyue Pan1 and  Yongming Wu1*
  • 1Department of Neurology, Nanfang Hospital, Southern Medical University, China

Background and Purpose: The 40-Hz steady state response (SSR) reflects early sensory processing and has the potential to differentiate disease severity. This study aims to evaluate the predictive value of 40-Hz SSR on the prognosis of patients with large hemispheric infarction (LHI).
Methods: We conducted a retrospective study in patients with LHI admitted to the neurological intensive care unit (NICU) of Nanfang Hospital, Southern Medical University, Guangzhou, China, between June 2008 and December 2014. 40-Hz SSR was recorded within 72 hours of the onset and categorized into 3 grades. The correlation between 40-Hz SSR grading and clinical outcome was examined.
Results: Of 97 eligible participants, 41 (42.3%) died within 30 days and 68 (70.1%) ended up with poor outcome (modified Rankin Scale of 5 and 6) at 90 days after the onset of LHI. 40-Hz SSR correlated significantly with NIHSS score at admission and patient outcome. Moreover, 40-Hz SSR Grade III, with bilateral sine waves disappeared or couldn’t be identified clearly, had a specificity of 97% and a positive predictive value of 94% in predicting 90-day poor outcome, and had a specificity of 91% and a positive predictive value of 74% in predicting 30-day mortality.
Conclusions: 40-Hz SSR could be used as a simple and specific method in predicting poor prognosis after LHI.

Keywords: 40-Hz steady-state response, Large hemispheric infarction, neurocritical care, Mortality, Poor prognosis

Received: 05 Jul 2018; Accepted: 29 Nov 2018.

Edited by:

Liping Liu, Beijing Tiantan Hospital, Capital Medical University, China

Reviewed by:

Rick Gill, Loyola University Chicago, United States
Minjee Kim, Northwestern University, United States  

Copyright: © 2018 Wang, Huang, Wang, Wang, Ji, Pan and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Yongming Wu, Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China, yongmingwucn@hotmail.com