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Systematic Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2019.00008

Association Between Cortical Superficial Siderosis and Dementia in Patients with Cognitive Impairment: a Meta-analysis

Chenheng Zhou1, Keqin Liu2,  Shenqiang Yan3 and Ying Jin1*
  • 1First People's Hospital of Wenling, China
  • 2Hangzhou First People's Hospital, China
  • 3Second Affiliated Hospital, Zhejiang University School of Medicine, China

Background: It remains unclear whether cortical superficial siderosis (cSS) is associated with dementia and its subtype. We thus performed a meta-analysis to evaluate the relationship between dementia and cSS.
Methods: We searched EMBASE, PubMed and Web of Science for relevant studies assessing risk of dementia and prevalence of cSS in patients with cognitive impairment. Fixed-effects and random-effects models were performed.
Results: Seven eligible studies including 3218 patients with definite cognitive impairment were pooled in meta-analysis. The prevalence of cSS was 3.4%. The pooled analysis demonstrates odds ratio for cSS and dementia to be 1.60 (95% CI 1.04 to 2.44; p = 0.031). Subgroup analysis further indicated a significant association between cSS and Alzheimer's disease (AD) (OR = 2.01, 95% CI 1.34 to 3.02; p < 0.001), but not non-AD dementia (OR = 0.700, 95% CI 0.435 to 1.128; p = 0.143).
Conclusions: Our meta-analysis of available published data demonstrates an increased prevalence of dementia in the subjects with pre-existing cSS, especially for AD. These findings suggest cSS to be a a candidate imaging indicator for AD. Further longitudinal research is needed to investigate the clinical relevance.

Keywords: Dementia, Alzheimer's disease, Superficial siderosis, cognitive impairment, Meta-analysis

Received: 15 Sep 2018; Accepted: 04 Jan 2019.

Edited by:

Yi Yang, First Affiliated Hospital of Jilin University, China

Reviewed by:

Zhiyi Xie, West China Hospital, Sichuan University, China
Zhao Ye, Huashan Hospital Affiliated to Fudan University, China  

Copyright: © 2019 Zhou, Liu, Yan and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Ying Jin, First People's Hospital of Wenling, Wenling, 317500, China,