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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2019.00033

Functional network-based statistics reveal abnormal resting-state functional connectivity in minimal hepatic encephalopathy

Chuanyin Zhan1, Yong-Qing Gao1,  Tian-Xiu Zou1 and  Hua-Jun Chen1*
  • 1Fujian Medical University, China

Purpose: Whole-brain functional network analysis is an emerging methodology for exploring the mechanisms underlying hepatic encephalopathy (HE). This study aimed to identify the brain subnetwork that is significantly altered within the functional connectome in minimal HE (MHE), the earliest stage of HE.
Materials and Methods: The study enrolled 19 cirrhotic patients with MHE and 19 controls who underwent the resting-state functional magnetic resonance imaging and cognitive assessment based on the Psychometric Hepatic Encephalopathy Score (PHES). A whole-brain functional connectivity (FC) matrix was calculated for each subject. Then, network-based statistical analyses of the functional connectome were used to perform group comparisons, and correlation analyses were conducted to identify the relationships between FC alterations and cognitive performance.
Results: MHE patients showed significant reduction of positive FC within a subnetwork that predominantly involved the regions of the default-mode network, such as the bilateral posterior cingulate gyrus, bilateral medial prefrontal cortex, bilateral hippocampus and parahippocampal gyrus, bilateral angular gyrus, and left lateral temporal cortex. Meanwhile, MHE patients showed significant reduction of negative FC between default-mode network regions (such as the bilateral posterior cingulate gyrus, medial prefrontal cortex, and angular gyrus) and the regions involved in the somatosensory network (i.e., bilateral precentral and postcentral gyri) and the language network (i.e., the bilateral Rolandic operculum). The correlations of FC within the default-mode subnetwork and PHES results were noted.
Conclusion: Default-mode network dysfunction may be one of the core issues in the pathophysiology of MHE. Our findings support the notion that HE is a neurological disease related to intrinsic brain network disruption.

Keywords: Minimal hepatic encephalopathy, resting-state functional magnetic resonance imaging, Brain functional network, cognitive impairment, network based statistic

Received: 17 Oct 2018; Accepted: 10 Jan 2019.

Edited by:

Christian Gaser, Friedrich-Schiller-Universität Jena, Germany

Reviewed by:

Svenja Caspers, Institute of Anatomy I, University Hospital Dusseldorf, Germany
Xuntao Yin, Army Medical University, China  

Copyright: © 2019 Zhan, Gao, Zou and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Hua-Jun Chen, Fujian Medical University, Fuzhou, 350108, Fujian Province, China, chj0075@126.com