Impact Factor 3.508
2017 JCR, Clarivate Analytics 2018

Frontiers journals are at the top of citation and impact metrics

Case Report ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2019.00534

A Case of Human Viral Encephalitis Caused by Pseudorabies Virus Infection in China

 HongNa Yang1, Hui Han1,  Hao Wang1, Yi Cui1,  Han Liu1 and  Shifang Ding1*
  • 1Qilu Hospital of Shandong University, China

We report a human case of viral encephalitis caused by pseudorabies virus (PRV) in China. A 43-year-old man with no past medical history presented with high-grade fever, headache and tonic-clonic seizures as well as coma. Plain computer tomography (CT) brain imaging showed hypo-density in bilateral basal ganglia, bilateral occipital lobe, bilateral limbic lobe and left thalamic. Next-generation sequencing (NGS) confirmed the presence of PRV in cerebral spinal fluid (CSF). Regular polymerase chain reaction (PCR) was applied to confirm the presence of PRV in the CSF and blood. In addition, serological (immunological) tests were used to further validate the presence of PRV in the peripheral blood. This case suggested that it was possible for PRV to result in central nervous system infection of human and it was necessary for people to increase awareness of self-protection when contacting animals.

Keywords: pseudorabies virus, Viral Encephalitis, Herpes simplex encephalitis, Japanese encephalitis, Next-generation sequence

Received: 27 Dec 2018; Accepted: 03 May 2019.

Edited by:

U K. Misra, Sanjay Gandhi Post Graduate Institute of Medical Sciences, India

Reviewed by:

Pradeep K. Maurya, Dr.Ram Manohar Lohia Institute Of Medical Sciences, India
Sanjay Pandey, Maulana Azad Medical College, India  

Copyright: © 2019 Yang, Han, Wang, Cui, Liu and Ding. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Shifang Ding, Qilu Hospital of Shandong University, Jinan, China,