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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2019.00585

Ketone bodies in neurological diseases: focus on neuroprotection and underlying mechanisms

 Huajun Yang1, 2, Wei Shan1, 2, 3, 4,  Fei Zhu1, 2,  Jianping Wu1, 2, 4 and  Qun Wang1, 2, 3, 4*
  • 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China
  • 2National Center for Clinical Medicine of Neurological Diseases, China
  • 3Beijing Institute for Brain Disorders (BIBD), China
  • 4Advanced Innovation Center for Human Brain Protection, Capital Medical University, China

There is growing evidence that ketone bodies—derived from fatty acid oxidation and produced during fasting or consumption of high-fat diets—can exert broad neuroprotective effects in a group of neurological diseases. Although the mechanisms underlying the neuroprotective effects of ketone bodies have not been fully elucidated, studies in recent years provided abundant evidence suggesting that ketone bodies exert neuroprotective effects through possible mechanisms including anti-oxidative stress, maintaining energy supply, modulating the activity of deacetylation and inflammatory responses. Based on the neuroprotective effects, ketogenic diet has been applicated in the treatment of neurological diseases such as refractory epilepsy, Alzheimer’s Disease, Parkinson’s Disease, and traumatic brain injury. Ketogenic diet has great potential for clinical application, which needs to be further explored. Future studies are necessary to further specify the roles of components in ketone bodies and their therapeutic target and related pathways, so as to optimal the strategy and efficacy of ketogenic diet therapy.

Keywords: Ketogenic Diet, Ketone body, Neuroprotection, Neurological Disease, Mechanism

Received: 28 Feb 2019; Accepted: 17 May 2019.

Edited by:

Tianfu Li, Sanbo Brain Hospital of Capital Medical University, China

Reviewed by:

Dinesh Upadhya, Manipal Academy of Higher Education, India
Hanna Lu, The Chinese University of Hong Kong, China  

Copyright: © 2019 Yang, Shan, Zhu, Wu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Qun Wang, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, wangq@ccmu.edu.cn