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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2019.00903

Networks disrupted in linguistic variants of frontotemporal dementia

  • 1Hospital Universitario San Ignacio, Colombia
  • 2Pontifical Javeriana University, Colombia
  • 3BASPI, Faculty of Engineering, Pontifical Javeriana University, Colombia

The non-fluent / agrammatic variant of primary progressive aphasia (nfvPPA) and semantic variant (svPPA) of frontotemporal dementia (FTD) are neurodegenerative diseases. Previous works have shown alterations of fractional anisotropy (FA) and mean diffusivity (MD) from diffusion tensor images (DTIs). This manuscript is aimed at using DTI images to build a global tractography and to identify atrophy patterns of subcortical networks in each variant. Twenty patients with svPPA, 20 patients with nfvPPA, and 26 patients with behavioral variant of FTD (bvFTD) were included. An analysis based on the connectivity of structural networks showed changes in FA and MD in svPPA and nfvPPA with respect to bvFTD. Much damage in the internal networks of the left temporal lobe was found in svPPA patients; in contrast, patients with nfvPPA showed atrophy in networks from the basal ganglia to motor and premotor areas. Those findings support the dual stream model of speech and language

Keywords: Diffusion tensor imaging (DTI), Primary progressive aphasia (ppa), Frontotemporal dementia (FTD), Fractional Anisotropy (FA), White matter (WM), structural connectivity

Received: 08 Apr 2019; Accepted: 05 Aug 2019.

Edited by:

Daniel Abasolo, University of Surrey, United Kingdom

Reviewed by:

Cristian E. Leyton, University of Sydney, Australia
Jordi A. Matias-Guiu, Servicio de Neurología, Hospital Clínico San Carlos, Spain  

Copyright: © 2019 Reyes, Rueda, Matallana and Uriza. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mr. Pablo A. Reyes, Hospital Universitario San Ignacio, Bogotá, Colombia, reyes.p@javeriana.edu.co