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Clinical Trial ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2019.00929


 Sophie Caplain1, Gaelle Chenuc2,  Sophie Blancho3, Sébastien Marque2 and  NOZAR AGHAKHANI4*
  • 1Laboratoire de Psychopathologie et Neuropsychologie, Université Paris 8, France
  • 2Clinical Research Organization, Capionis, France
  • 3Institut pour la recherche sur la moelle epinière et l'encéphale, France
  • 4Department of neurosurgery, Bicêtre university hospital, Assistance Publique Hopitaux De Paris (AP-HP), France

Unfavourable outcomes (UO) are seen in 15 to 20% of patients with mild traumatic brain injury (mTBI). Early identification of patients at risk for UO is crucial for suitable management to be initiated, increasing their chances for a return to a normal life. We previously developed a diagnostic tool enabling early identification (8 to 21 days after the injury) of patients likely to develop UO. In the present study, we examine the value and beneficial effects of early multidimensional management (MM) on prognosis. We used our diagnostic tool to classify 221 mTBI patients as UO (97) or FO (favourable outcome) (124). Patients whose initial risk factors point to UO are at risk of developing post-concussion syndrome (PCS). We randomized UO patients into 2 groups: a group that underwent MM (cognitive-behavioural rehabilitation) (34) and a group with no specific management (46). At 6 months, these 2 groups were compared and the impact of MM on outcome was assessed. Among patients initially classified as FO (101), 95% had FO at 6 months and only 5 had PCS as defined by DSM-IV classification. Of the UO patients who received MM, 94% had no PCS 6 months after injury, whereas 52% of the UO patients who did not receive MM had persistent PCS. The effect of MM on the recovery of patients at 6 months, once adjusted for the main confounding factors, was statistically significant (p<0.001). These results show that the initiation of MM after early identification of at-risk mTBI patients can considerably improves their prognosis.

Keywords: mild TBI, post concussion symptoms, Rehabilatation, Quality of Life, human

Received: 23 Jan 2019; Accepted: 09 Aug 2019.

Copyright: © 2019 Caplain, Chenuc, Blancho, Marque and AGHAKHANI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. NOZAR AGHAKHANI, Assistance Publique Hopitaux De Paris (AP-HP), Department of neurosurgery, Bicêtre university hospital, Paris, France,