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Systematic Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2019.00943

The P300 event-related potential component and cognitive impairment in epilepsy: A systematic review and meta-analysis

 Weihong Lin1*, Guangjian Li1*, Rui Zhong1, Qingling Chen2 and Jing Li1
  • 1Department of Neurology, First Hospital of Jilin University, China
  • 2Department of Hepatology, First Affiliated Hospital of Jilin University, China

Abstract
Background
Epilepsy is one of the most prevalent chronic brain diseases worldwide and is often accompanied by cognitive impairment. Event-related potentials (ERPs) are an objectively noninvasive approach for studying information processing and cognitive functions in the brain. The P300 is an important and extensively explored late component of ERPs that has been widely applied to assess cognitive function in epilepsy in previous studies. However, consistent conclusions have not yet been reached for various reasons.
Objective
We conducted a comprehensive systematic review and meta-analysis of P300-related studies to assess the latency and amplitude of the P300 in epileptic patients.
Methods
PubMed, EMBASE, and Cochrane Library databases were systematically searched for eligible studies. The standard mean difference (SMD) and the 95% confidence interval (CI) were calculated as the effect size of the P300 component.
Results
The main results of the present meta-analysis indicated that epileptic patients have a longer P300 latency and a lower P300 amplitude than controls. Subgroup analysis based on age group demonstrated that these differences can be observed in both children and adult patients compared with healthy controls. In addition, the P300 latency was longer in patients with the five main types of epileptic seizures than in controls.
Conclusion
This study revealed that epileptic patients have abnormalities in the P300 component, which may reflect deficits in cognitive function. Thus, the P300 may be a potential objective approach for evaluating cognitive function in epileptic patients.

Keywords: P300 - event related potential, Cognitive impairment (CI), Epilepsy, Meta - analysis, P300 latency, P300 amplitude

Received: 18 Mar 2019; Accepted: 14 Aug 2019.

Copyright: © 2019 Lin, Li, Zhong, Chen and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Weihong Lin, Department of Neurology, First Hospital of Jilin University, Changchun, China, z415831003@outlook.com
Dr. Guangjian Li, Department of Neurology, First Hospital of Jilin University, Changchun, China, Liguangjian555@126.com