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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2019.00948

Subcellular abnormalities of vestibular nerve morphology in patients with intractable Meniere 's disease

 Pengjun Wang1,  Huaming Zhu1, Wen Lu1, Qiang Song1, Zhengnong Chen1, Yaqin Wu1,  Hui Wang1,  Dongzhen Yu1*, Haibo Ye1*,  Haibo Shi2* and  Shankai Yin2
  • 1Department of Otolaryngology–Head and Neck Surgery, Shanghai Sixth People's Hospital, China
  • 2Shanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology–Head and Neck Surgery, Shanghai Sixth People's Hospital, China

Objective: Few studies so far have focused on the retrocochlear lesions in Meniere’s disease (MD). This study aims to investigate pathological alterations in the central portion of the vestibular nerve (VN) in patients with intractable Meniere’s disease (MD) and to explore retrocochlear lesions and their relationship with disease severity.
Methods: Eight MD patients with refractory vertigo received vestibular neurectomy via a retrosigmoid or translabyrinthine approach. Segments of VN were carefully removed and immediately fixed for histopathological examination. Five VN specimens were examined by light microscopy after hematoxylin/eosin staining; three specimens were extensively analyzed using transmission electron microscopy, to identify VN ultrastructural lesions. Correlations between lesions and patient clinical characteristics were examined.
Results: Histopathological examination revealed evidence of various types of chronic VN impairment, including the formation of corpora amylacea (CA), axon atrophy, and severe damage to the myelin sheath. Electron microscopy revealed membranous whorls within dilated Schmidt–Lanterman incisures, the formation of myeloid bodies, dysmyelination, and demyelination. Unexpectedly, we observed a positive correlation between the density of CA in VN tissue and the duration of disease, as well as the degree of hearing impairment, independent of age.
Conclusion: Our findings indicate that deformation of subcellular organelles in the central portion of the VN is one of the key pathological indicators for the progressive severity and intractability of vertigo and support a vestibular nerve degeneration.

Keywords: Neurectomy, Vestibular neuropathy, Vertigo, Meniere's disease, ultrastructural deformation

Received: 10 Apr 2019; Accepted: 16 Aug 2019.

Copyright: © 2019 Wang, Zhu, Lu, Song, Chen, Wu, Wang, Yu, Ye, Shi and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Mx. Dongzhen Yu, Department of Otolaryngology–Head and Neck Surgery, Shanghai Sixth People's Hospital, Shanghai, Shanghai Municipality, China, dzyu2013@126.com
Dr. Haibo Ye, Department of Otolaryngology–Head and Neck Surgery, Shanghai Sixth People's Hospital, Shanghai, Shanghai Municipality, China, yehaibo_2012@163.com
Prof. Haibo Shi, Department of Otolaryngology–Head and Neck Surgery, Shanghai Sixth People's Hospital, Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, Shanghai Municipality, China, hbshi@sjtu.edu.cn