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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2019.01091

Reliability of Assessing Non-severe Elevation of Intracranial Pressure Using Optic Nerve Sheath Diameter and Transcranial Doppler Parameters

Li-min Chen1, Li-juan Wang1, Lin Shi2, Hong-xiu Chen1, Xiao-han Jiang1, Qian-qian Chen1 and  Ying-qi Xing1*
  • 1Department of Neurology, First Hospital of Jilin University, China
  • 2Department of Neurosurgery, The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, China

Background/Aims: Non-invasive measurement of intracranial pressure (ICP) using ultrasound has garnered increasing attention. This study aimed to compare the reliability of ultrasonographic measurement of optic nerve sheath diameter (ONSD) and transcranial doppler (TCD) in detecting potential ICP elevations.
Methods: Patients who needed lumbar puncture (LP) in the Department of Neurology were recruited from December 2016 to July 2017. The ONSD and TCD measurements were completed before LP.
Results: One hundred and sixty five participants (mean age, 41.96±14.64 years; 80 men; 29 patients with elevated ICP) were included in this study. The mean ICP was 170±52 mmH2O (range75–400mmH2O). Univariate analyses revealed that ICP was non-significantly associated with TCD parameters and significantly associated with ONSD (r=0.60, P<0.001). The mean ONSD of the elevated ICP group was significantly higher than that of the normal ICP group (4.53±0.40 mmvs3.97±0.23 mm; P<0.001). Multivariate linear regression determined that the difference between ICP and ONSD is significant.
Conclusions: In the early stage of intracranial hypertension, ONSD is more reliable for evaluating ICP than TCD.

Keywords: Intracranial Pressure, transcranial Doppler, Ultrasonography, optic nerve sheath diameter, non-invasive

Received: 07 Jul 2019; Accepted: 30 Sep 2019.

Copyright: © 2019 Chen, Wang, Shi, Chen, Jiang, Chen and Xing. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Ying-qi Xing, Department of Neurology, First Hospital of Jilin University, Changchun, China, xingyq2009@sina.com