Brief Research Report ARTICLE
A novel porcine model for the study of cerebrospinal fluid dynamics: Development and preliminary results
- 1Mechanical and Aerospace Engineering, North Carolina State University, United States
- 2Radiology, University of North Carolina at Chapel Hill, United States
- 3Ophthalmology, University of North Carolina at Chapel Hill, United States
- 4Otolaryngology, Head & Neck Surgery, University of North Carolina at Chapel Hill, United States
- 5School of Medicine, University of North Carolina at Chapel Hill, United States
Idiopathic intracranial hypertension, space-flight associated neuro-ocular syndrome (SANS), and glaucoma are conditions that are among a spectrum of cerebrospinal fluid (CSF)-related ophthalmologic disease. This implies that local CSF pressures at the level of the optic nerve are involved to variable extent in these disease processes. However, CSF pressure measurements are problematic due to invasiveness and interpretation. The pressure measured by a lumbar puncture is likely not the same as the orbital CSF pressure. It is believed this is at least in part due to the flow restrictive properties of the optic canal. A model for CSF dynamics was created using three medium-sized pigs. Contrast was administered through a lumbar subarachnoid space access. The contrast front was imaged with repeated computed tomographic (CT) imaging. Once contrast entered the orbit, rapid, sequential CT imaging was performed until the contrast reached the posterior globe. Head tilting was performed accentuating to highlight the role of gravitational dependence within the subarachnoid space.
Keywords: CSF, CSF pressure, Optic canal, Glaucoma, Papilledema, space-flight associated neuro-ocular syndrome, translaminar pressure
Received: 21 May 2019;
Accepted: 10 Oct 2019.
Copyright: © 2019 Kaskar, Shams, Zhang, Olson, Zdanski, Thorp, Kuznetsov, Grace, Lee and Fleischman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dr. David Fleischman, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, United States, email@example.com