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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2019.01230

Triglyceride Level is an Independent Risk Factor in First-Attacked Neuromyelitis Optica Spectrum Disorders Patients

 Kaimin Wu1,  Lulu Wen1, Ranran Duan1, Yanfei Li1, Yaobing Yao1, Lijun Jing1,  Yanjie Jia1, Junfang Teng1 and  Qianyi He1*
  • 1Department of Neurolgoy, First Affiliated Hospital of Zhengzhou University, China

Abstract
Objective To investigate prospective associations between triglyceride (TG) level and prognosis of first-attacked patients with neuromyelitis optica spectrum disorders (NMOSD).
Methods This retrospective study included 196 patients newly diagnosed with NMOSD from June 2014 to December 2018. Data of clinical parameters, including age of onset, sex, BMI, blood lipid levels, anti-aquaporin-4 status, serum glucose level, therapy regimens, comorbidities, initial Expanded Disability Status Scale (EDSS), relapses, and outcomes were collected. We used logistic regression models to examine the associations among relevant clinical factors and outcomes, and statistical analyses were performed using the SPSS 23.0 software.
Results Compared with the high TG group, residual EDSS was relatively lower in the normal TG group (median 1.0 vs. 2.0, P=0.002). In the univariate analysis, TG level was positively correlated with outcomes (OR 1.75, 95% CI 1.18-2.60, P=0.005) and relapses (OR 1.57, 95% CI 1.07-2.31, P=0.02). Our stratified analysis suggested that patients with normal BMI (OR 4.90,95% CI 2.10-11.44, P=0.001) were closely correlated with poor recovery owing to increased TG level. In the multivariate analysis, a statistically significant association still existed between TG level and outcomes (OR 3.44, 95% CI 1.02-11.64; P=0.040) after adjusting for various variables.
Conclusions In first-attacked NMOSD patients, TG level was positively associated with poor recovery. Early monitoring and treatment of elevated TG level in NMOSD patients are important.

Keywords: neuromyelitis optica spectrum disorders, the first-attacked patients, Triglyceride level, outcomes, relapse

Received: 25 Aug 2019; Accepted: 05 Nov 2019.

Copyright: © 2019 Wu, Wen, Duan, Li, Yao, Jing, Jia, Teng and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Qianyi He, Department of Neurolgoy, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, fccheqy@zzu.edu.cn