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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2019.01231

Effect of LRRK2 G2385R variant on subthalamic deep brain stimulation efficacy for Parkinson’s disease in a Han Chinese population

Si Chen1, Hong Liu2, Qian-qian Wu1, Shu-jun Xu1, Wei-guo Li1, Teng Chen1, Chao Li1, Xiang-yu Ma1, Shuo Xu1 and  Yiming Liu1*
  • 1Qilu Hospital, Shandong University, China
  • 2Liaocheng People's Hospital, China

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for advanced Parkinson’s disease (PD). The G2385R variant of LRRK2 is a risk factor for PD in Han Chinese individuals. We retrospectively compared the clinical outcomes of STN-DBS surgery between PD Han Chinese G2385R variant carriers and non-carriers. Fifty-seven PD patients with bilateral STN-DBS were enrolled, including 8 G2385R+ variant carriers (G2385R+ group) and 49 non-carriers (G2385R- group). Clinical data included Unified Parkinson’s Disease Rating Scale (UPDRS) parts I to IV, levodopa equivalent daily dose (LEDD), Mini-Mental State Examination Scale (MMSE) score, and Hamilton Depression Rating Scale (HAMD) score measured prior to DBS and 12 months post-DBS. DBS settings were also recorded. All PD patients benefited from STN-DBS surgery. There were no statistical differences between the two groups in terms of motor function, daily living activities, and LEDD reductions at 12 months post-DBS. The rigidity of the post-surgical G2385R+ group was significantly improved compared with that of the G2385R- group (P=0.045). Post-surgical voltage in the G2385R+ group was significantly higher than that in the G2385R- group (P=0.033). STN-DBS outcomes were not influenced by the LRRK2 G2385R variant in Han Chinese patients.

Keywords: Parkinson’s disease, Deep Brain Stimulation, Han Chinese, LRRK2, STN-DBS surgery

Received: 19 Aug 2019; Accepted: 05 Nov 2019.

Copyright: © 2019 Chen, Liu, Wu, Xu, Li, Chen, Li, Ma, Xu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Yiming Liu, Qilu Hospital, Shandong University, Jinan, Shandong Province, China, liuym@sdu.edu.cn