Front. Neurol.
Sec. Neuroinfectious Diseases
doi: 10.3389/fneur.2022.873694

Acute invasive mucormycosis rhinosinusitis causing multigroup cranial nerve injury and meningitis—a case report

  • 1Department of Neurology, Harrison International Peace Hospital, China
  • 2Department of Neurology, Harrison International Peace Hospital, Hengshui, Hebei, 053000, China, China
Provisionally accepted:
The final, formatted version of the article will be published soon.

In this study, we report a case of a Rhino-Orbital-Cerebral Mycosis (ROCM) patient with multiple groups of cranial nerve damage as the primary clinical manifestation and confirmed by histopathology and cerebrospinal fluid metagenomic next-generation sequencing (mNGS) technology. Relying on the MRI3D-SPACE technology, we observed the location and extent of the patient's cranial nerve damage. The results suggest that fungal meningoencephalitis caused by mucor may enter the skull retrograde along the cranial nerve perineurium. The patient was admitted to the hospital with a preliminary diagnosis of mucormycosis infection after 1.5 days of mouth deviation. We treated the patient immediately with intravenous amphotericin B liposomes. After 21 days of hospitalization, the patient's clinical symptoms did not improve significantly. The patient was discharged due to financial difficulties and antifungal treatment at home, and his disease stabilized at the 6-month follow-up.

Keywords: Mucor, Cranial nerve, 3D-SPACE technology, MNGs, Infection

Received: 11 Feb 2022; Accepted: 09 Aug 2022.

Copyright: © 2022 Tingting, Cao and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mr. Jingzhe Han, Department of Neurology, Harrison International Peace Hospital, Hengshui, Hebei, 053000, China, Hengshui, Hebei, China