Interactions between Nanoparticles and Dendritic Cells: From the Perspective of Cancer Immunotherapy
- 1Collaborative Innovation Center of Water Quality Safety and Protection in Pearl River Delta Water, China
- 2School of Chemistry and Chemical Engineering, Shandong University, China
- 3School of Environmental Science and Engineering, Shandong University, China
Dendritic cells (DCs) are the primary antigen-presenting cells and play key roles in the orchestration of the innate and adaptive immune system. Targeting DCs by nanotechnology stands as a promising strategy for cancer immunotherapy. The physicochemical properties of nanoparticles (NPs) influence their interactions with DCs, thus altering the immune outcome of DCs by changing their functions in the processes of maturation, homing, antigen processing and antigen presentation. In this review, we summarize the recent progress in targeting DCs using NPs as a drug delivery carrier in cancer immunotherapy, the recognition of NPs by DCs, and the ways the physicochemical properties of NPs affect DCs’ functions. Finally, the molecular mechanisms underlying these effects are also discussed.
Keywords: Nanoparticles, Physiochemical properties, DC targeting, cancer immunotherapy, DC functions
Received: 28 Jun 2018;
Accepted: 04 Sep 2018.
Edited by:Giuseppe Giaccone, Georgetown University, United States
Reviewed by:Lina Ghibelli, Università degli Studi di Roma Tor Vergata, Italy
Chao Wang, University of North Carolina at Chapel Hill, United States
Copyright: © 2018 Jia, Zhang, Xin, Jiang, Yan and Zhai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Prof. Bing Yan, School of Environmental Science and Engineering, Shandong University, Jinan, China, firstname.lastname@example.org
Dr. Shumei Zhai, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong Province, China, email@example.com