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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.00120

MiR-1-3p inhibits lung adenocarcinoma cell tumorigenesis via targeting protein regulator of cytokinesis 1

Tao Li1, Xiuxiu Wang1, Lijun Jing1 and  Yu Li1*
  • 1Qilu Hospital of Shandong University, China

Lung adenocarcinoma (LUAD) is one of the most lethal malignancies, posing a threat to human health. However, the molecular mechanisms underlying LUAD development remain largely unknown. In this study, we found that miR-1-3p was significantly downregulated in human LUAD tissues and cell lines and played an inhibitory role in LUAD cell tumorigenesis, as evidenced by the significantly reduced proliferation, migration, and invasion of LUAD cells in response to miR-1-3p overexpression. Mechanistically, miR-1-3p physically interacted with the 3ʹ-untranslated region (UTR) of protein regulator of cytokinesis 1 (PRC1) mRNA, leading to downregulation of PRC1. Overexpression of PRC1 reversed the inhibitory effects of miR-1-3p on LUAD cell tumorigenesis, suggesting that the miR-1-3p/PRC1 axis is majorly involved in suppressing LUAD development and progression. Consistently, PRC1 was dramatically induced in LUAD tissues and cell lines as well as associated with a poor prognosis in LUAD patients. Taken together, our study identified the miR-1-3p/PRC1 axis as an important regulatory mechanism contributing to LUAD inhibition and provided valuable clues for the future development of therapeutic strategies against LUAD.

Keywords: Lung Adenocarcinoma, MiR-1-3p, Protein regulator of cytokinesis 1, metastasis, prognosis

Received: 13 Nov 2018; Accepted: 11 Feb 2019.

Edited by:

Jian-ye Zhang, Guangzhou Medical University, China

Reviewed by:

Frank Arfuso, Curtin University, Australia
Kuzhuvelil B. Harikumar, Rajiv Gandhi Centre for Biotechnology, India  

Copyright: © 2019 Li, Wang, Jing and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Yu Li, Qilu Hospital of Shandong University, Jinan, Shandong Province, China, qlliyures@163.com