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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.00161

E2F2/5/8 serve as potential prognostic biomarkers and targets for human ovarian cancer

 Quan Zhou1*, Fan Zhang1, Ze He1 and Man-Zhen Zuo1
  • 1China Three Gorges University, China

E2Fs is a family of pivotal transcription factors. Accumulative evidence indicated that aberrant expression or activation of the E2Fs is a common phenomenon in malignances, and the significant associations between E2Fs and tumorigenesis or progression in a wide range of cancers. However, the expression patterns and exact roles of each E2Fs contributing to tumorigenesis and progression of ovarian cancer (OC) are yet to be elucidated. In the current study, we report the distinct expression and prognostic value of E2Fs in patients with OC through analysis of a series of databases, including ONCOMINE, GEPIA, cBioPortal, Metascape and Kaplan–Meier plotter. It was found that mRNA expression levels of E2F1/2/3/5/8 were significantly upregulated in patients with OC, and obvious associated with tumor stage for OC. Aberrant expressions of E2F2/5/7/8 were found to be associated with the clinical outcomes of patients with OC. These results suggest that E2F2/5/8 may serve as potential prognostic biomarkers and targets for OC. However, future studies are required to validate our findings and thus promote the clinical utility of E2Fs in OC.

Keywords: Prognostic value, E2Fs, ovarian cancer, Database mining, Bioinformatics analysis

Received: 14 Nov 2018; Accepted: 25 Feb 2019.

Edited by:

Jian-Jun Wei, Northwestern University, United States

Reviewed by:

Kruti P. Maniar, Department of Pathology, Feinberg School of Medicine, Northwestern University, United States
Zhaojian Liu, Shandong University, China  

Copyright: © 2019 Zhou, Zhang, He and Zuo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Quan Zhou, China Three Gorges University, Yichang, China, zhouquan8519@163.com