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Front. Oncol. | doi: 10.3389/fonc.2019.00779

Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications

  • 1University of Seville, Spain
  • 2Department of Physiology, University of Seville, Spain

Human glioblastoma is the most aggressive type of primary malignant brain tumors. Standard treatment includes surgical resection followed by radiation and chemotherapy but it only provides short-term benefits and the prognosis of these brain tumors is still very poor. Glioblastomas contain a population of glioma stem cells (GSCs), with self-renewal ability, which are partly responsible for the tumor resistance to therapy and for the tumor recurrence after treatments.
The human adult subventricular zone contains astrocyte-like neural stem cells (NSCs) that are probably reminiscent of the radial glia present in embryonic brain development. There are numerous molecules involved in the biology of subventricular zone NSCs that are also instrumental in glioblastoma development. These include cytoskeletal proteins, telomerase, tumor suppressor proteins, transcription factors and growth factors. Interestingly, genes encoding these molecules are frequently mutated in glioblastoma cells. Indeed, it has been recently shown that NSCs in the subventricular zone are a potential cell of origin that contains the driver mutations of human glioblastoma. In this review we will describe common features between GSCs and subventricular zone NSCs, and we will discuss the relevance of this important finding in terms of possible future therapeutic strategies.

Keywords: Glioblastoma stem cells, Tumor Microenvironment, adult neurogenesis, Neural Stem Cells, Subventricular zone

Received: 26 Mar 2019; Accepted: 31 Jul 2019.

Edited by:

Edjah K. Nduom, National Institutes of Health (NIH), United States

Reviewed by:

Justin Lathia, Cleveland Clinic Lerner College of Medicine, United States
Kristin Huntoon, The Ohio State University, United States
Pierpaolo Peruzzi, Brigham and Women's Hospital, Harvard Medical School, United States  

Copyright: © 2019 Matarredona and Pastor. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Esperanza R. Matarredona, University of Seville, Seville, Spain,