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CASE REPORT article

Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1360158

Adult ovarian and sellar region mixed germ cell tumor: A case report and literature review

Provisionally accepted
Dawei Chen Dawei Chen 1*Anling Zhang Anling Zhang 2Kun Xue Kun Xue 1Shuyu Liu Shuyu Liu 1Xu Yan Xu Yan 1
  • 1 First Affiliated Hospital of Jilin University, Changchun, China
  • 2 Jilin FAW General Hospital, Changchun, Hebei Province, China

The final, formatted version of the article will be published soon.

    Mixed germ cell tumors (mGCTs) involving both the ovaries and sellar region have been rarely reported; thus, they pose significant challenges in clinical management. Our report of a case of a 26-year-old female with left ovarian mGCTs (dysgerminoma + yolk sac tumor) who presented with postoperative headaches and blurred vision contributes new information to the literature on treating mGCTs, which can lead to standardized regimens and sequencing guidelines. A physical examination revealed right temporal hemianopia, and elevated levels of alpha-fetoprotein were detected in serum and cerebrospinal fluid. Magnetic resonance imaging (MRI) of the sellar region revealed a space-occupying lesion. Pathological examination of the tumor after endoscopic transnasal resection confirmed the diagnosis of mGCTs (germinomas + yolk sac tumor). The patient received adjuvant chemotherapy and radiotherapy at reduced dosages. During follow-up, tumor markers remained within normal limits, and there was no evidence of tumor recurrence on sellar region MRI. This case highlights the rarity of the simultaneous occurrence of ovarian and sellar region mGCTs and emphasizes the importance of accurate diagnosis and multidisciplinary management.

    Keywords: Mixed germ cell tumors, ovarian tumor, Sellar region tumor, Alphafetoprotein, Endoscopic Surgery

    Received: 22 Dec 2023; Accepted: 06 May 2024.

    Copyright: © 2024 Chen, Zhang, Xue, Liu and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Dawei Chen, First Affiliated Hospital of Jilin University, Changchun, China

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