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REVIEW article

Front. Oncol.
Sec. Cancer Genetics
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1383062

Revitalizing Oral Cancer Research: Crispr-Cas9 Technology and the Promise of Genetic Editing

Provisionally accepted
Sowmya S V Sowmya S V 1Dominic Augustine Dominic Augustine 1*Shazia Mushtaq Shazia Mushtaq 2Hosam A. Baeshen Hosam A. Baeshen 3Heba Ashi Heba Ashi 3Reem N. Hassan Reem N. Hassan 3Mohammed Alshahrani Mohammed Alshahrani 3Shankargouda Patil Shankargouda Patil 4
  • 1 M S Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India
  • 2 King Saud University, Riyadh, Riyadh, Saudi Arabia
  • 3 King Abdulaziz University, Jeddah, Makkah, Saudi Arabia
  • 4 College of Dental Medicine, Roseman University of Health Sciences, South Jordan, Utah, United States

The final, formatted version of the article will be published soon.

    This review presents an in-depth analysis of the immense potential of CRISPR-Cas9 technology in revolutionizing oral cancer research. It underscores the inherent limitations of conventional treatments while emphasizing the pressing need for groundbreaking approaches. The unparalleled capability of CRISPR-Cas9 to precisely target and modify specific genes involved in cancer progression heralds a new era in therapeutic intervention. Employing genome-wide CRISPR screens, vulnerabilities in oral cancer cells can be identified, thereby unravelling promising targets for therapeutic interventions. In the realm of oral cancer, the disruptive power of CRISPR-Cas9 manifests through its capacity to perturb genes that are intricately associated with drug resistance, consequently augmenting the efficacy of chemotherapy. To address the challenges that arise, this review diligently examines pertinent issues such as off-target effects, efficient delivery mechanisms, and the ethical considerations surrounding germline editing. Through precise gene editing, facilitated by CRISPR/Cas9, it becomes possible to overcome drug resistance by rectifying mutations, thereby enhancing the efficacy of personalized treatment strategies. This review delves into the prospects of CRISPR-Cas9, illuminating its potential applications in the domains of medicine, agriculture, and biotechnology. It is paramount to emphasize the necessity of ongoing research endeavours and the imperative to develop targeted therapies tailored specifically for oral cancer. By embracing this comprehensive overview, we can pave the way for ground-breaking treatments that instill renewed hope for enhanced outcomes in individuals afflicted by oral cancer.

    Keywords: CRISPR-Cas9, gene editing, oral cancer, CRISPR-screens, Genetic editing

    Received: 06 Feb 2024; Accepted: 08 May 2024.

    Copyright: © 2024 S V, Augustine, Mushtaq, Baeshen, Ashi, Hassan, Alshahrani and Patil. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Dominic Augustine, M S Ramaiah University of Applied Sciences, Bengaluru, 560054, Karnataka, India

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.