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Front. Pharmacol. | doi: 10.3389/fphar.2018.00135

Jab1/COPS5 as a Novel Biomarker for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Human Cancer

  • 1Wuhan University, China
  • 2University of Texas MD Anderson Cancer Center, United States

C-Jun activation domain-binding protein-1 (Jab1) involves in controlling cellular proliferation, cell cycle, apoptosis, affecting a series of pathways, as well as regulating genomic instability and DNA damage response. Jab1/COPS5 dysregulation contributes to oncogenesis by deactivating several tumor suppressors and activating oncogenes. Jab1 overexpression was found in many tumor types, illuminating its important role in cancer initiation, progression, and prognosis. Jab1/COPS5 has spurred a strong research interest in developing inhibitors of oncogenes/oncoproteins for cancer therapy. In this paper, we present evidences demonstrating the importance of Jab1/COPS5 overexpression in several cancer types and recent advances in dissecting the Jab1/COPS5 upstream and downstream signaling pathways. By conducting ingenuity pathway analysis (IPA) based on the Ingenuity Knowledge Base, and querying the web-based oncomine microarray database, we investigated signaling network that interacts with Jab1/COPS5. The data confirmed the important role of Jab1/COPS5 in tumorigenesis, demonstrating the potential of Jab1/COPS5 to be used as a biomarker for cancer patients, and further support that Jab1/COPS5 may serve as a potential therapeutic target in different cancers.

Keywords: jab1, biomarker, prognostic marker, Therapeutic target, cops5

Received: 17 Nov 2017; Accepted: 07 Feb 2018.

Edited by:

Zhi Sheng, Virginia Tech, United States

Reviewed by:

Paul B. Fisher, Virginia Commonwealth University, United States
Harikumar KB, Rajiv Gandhi Centre for Biotechnology, India  

Copyright: © 2018 Liu, Claret, Zhou and Pan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Yunbao Pan, Wuhan University, Wuhan, China, panyunbao@outlook.com