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Front. Pharmacol. | doi: 10.3389/fphar.2018.00444

A Review on The effect of Traditional Chinese Medicine against Anthracyclines-Induced Cardiac Toxicity

Xinyu Yang1, 2,  Nian Liu3,  Xinye Li1, 2, Yihan Yang1, 2, Xiaofeng Wang2, Linling Li3, Le Jiang3,  Yonghong Gao1, 2,  Yanwei Xing1* and Hongcai Shang2*
  • 1Guang’anmen Hospital, China Academy of Chinese medical Science, China
  • 2Dongzhimen Hospital, Beijing University of Chinese Medicine, China
  • 3Beijing Anzhen Hospital, China

Anthracyclines are effective agents generally used to treat solid-tumor malignancies and hematologic malignancies. The widely use of anthracyclines for over 40 years has quite improved cancer survival statistics. Nevertheless, clinical utility is restricted by dose-dependent cardiotoxicity that adversely affects 10%-30% of patients. Anthracyclines-induced cardiotoxicity may be sorted as acute/subacute or chronic/late toxicity, becoming a devastating adverse effect resulting in poor quality of life, morbidity, and premature mortality. Traditional Chinese Medicine, has a history of over 2,000 years, with both unique theories and ample experience. Several studies have researched the potential of natural products in decreasing the cardiotoxicity effects of chemotherapeutic agents on healthy cells, while unaffected their antineoplastic activity. This article discusses the mechanism of anthracyclines-induced cardiotoxicity, and summarizes traditional Chinese medicine treatment on anthracyclines-induced heart failure (HF), cardiac arrhythmia, cardiomyopathy, and myocardial ischemia Chinesein recent years, in order to provide a reference for clinical prevention and treatment of cardiac toxicity.

Keywords: Anthracyclines, Traditional Chinese Medicine, cardiac toxicity, adverse effects, Antineoplastic

Received: 16 Dec 2017; Accepted: 16 Apr 2018.

Edited by:

Lyndy J. McGaw, University of Pretoria, South Africa

Reviewed by:

Jianxin Chen, Beijing University of Chinese Medicine, China
Ana Sabo, Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Serbia
FLORA PIROZZI, University of Naples Federico II, Italy  

Copyright: © 2018 Yang, Liu, Li, Yang, Wang, Li, Jiang, Gao, Xing and Shang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Yanwei Xing, Guang’anmen Hospital, China Academy of Chinese medical Science, Beijing, China,
Dr. Hongcai Shang, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China,