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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2018.01359

Diagnostic performance of Multiple Sound Touch Elastography for differentiating benign and malignant thyroid nodules

Lei Zhang1, Zhimin Ding1,  Fajin Dong1, 2, 3*, Huaiyu Wu1, Weiyu Liang1, Hongtian Tian1, Xiuqin Ye1, Hui Luo1 and Jinfeng Xu1
  • 1Shenzhen People’s Hospital, China
  • 2Ultrasound, Second Clinical Medicine College, Jinan University, China
  • 3Southern University of Science and Technology, China

This study evaluated the ability of Sound Touch Elastography (STE) to distinguish malignant from benign thyroid nodules by quantifying tumor stiffness using the elastic ratio (EI) and shear modulus (G). Eighty-six patients with 86 nodules were enrolled in this study. There were 24/86 (27.90%) thyroid papillary carcinomas (TPC) and 62/86 (72.10%) benign nodules. The mean EI was significantly lower in TPCs than in benign nodules. The EI area under the receiver operating characteristic curve (ROC) was 80%. The EI cutoff value for TPCs was 0.215%. The sensitivity (Sen), specificity (Spe), positive likelihood ratio (LR+), and negative likelihood ratio (LR-) were 71%, 73%, 2.58, and 0.40, respectively. Gmax, Gmean, and Gsd were significantly higher in TPCs than in benign nodules. There were no significant differences in Gmin. Compared with other G parameters, Gmax with an optimal cutoff value of 15.82 kPa had the highest AUROC value (84%). The Sen, Spe, LR+, and LR- were 79.17%, 79.03%, 3.776, and 0.261, respectively. We pooled the EI, Gmax, Gmean, and Gsd and the pooled-Sen, Spe, -LR+, LR-, diagnostic odds ratio, ​and odds ratio, and area under the summary ROC were 79%, 71%, 2.73,0.29, 2.23, 9.29, and 82%, respectively. STE could be a new ultrasound diagnostic method for evaluating benign and malignant thyroid nodules.

Keywords: Sound Touch Elastography, Thyroid cancer (TC), Shear modulus (G), summary receiver operating characteristic curve, diagnosis

Received: 11 Sep 2018; Accepted: 05 Nov 2018.

Edited by:

Fei Yan, Shenzhen Institutes of Advanced Technology (CAS), China

Reviewed by:

Cui L. Gang, Peking University Third Hospital, China
JianQiao Zhou, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, China  

Copyright: © 2018 Zhang, Ding, Dong, Wu, Liang, Tian, Ye, Luo and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Fajin Dong, Second Clinical Medicine College, Jinan University, Ultrasound, Shenzhen, China, fajindong@ext.jnu.edu.cn