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Front. Pharmacol. | doi: 10.3389/fphar.2018.01453

Therapeutic Potential of Nitrogen Mustard Based Hybrid Molecules

Yiming Chen1, Yuping Jia2, Weiguo Song1 and  Lei Zhang1*
  • 1Weifang Medical University, China
  • 2Shandong Academy of Pharmaceutical Science, China

As medicine advances, cancer is still among one of the major health problems, posing significant threats to human health. New anticancer agents features with novel scaffolds and/or unique mechanisms of action are highly desirable for the treatment of cancers, especially those highly aggressive and drug-resistant ones. Nitrogen mustard has been widely used as an anticancer drug since the discovery of its antitumor effect in the 1942. However, the lack of selectivity to cancer cells restricts the wide usage of a mass of nitrogen mustard agents to achieve further clinical significance. Discovery of antitumor hybrids using nitrogen mustards as key functional groups has exhibited enormous potential in the drug development. Introduction of nitrogen mustards resulted in improvement in the activity, selectivity, targetability, safety, pharmacokinetics and pharmacodynamics properties of corresponding lead compounds or agents. Herein, the recently developed nitrogen mustard based hybrids have been introduced in the cancer therapy.

Keywords: antitumor, Nitrogen mustard, Hybrids, side effects, Drug Discovery

Received: 31 Oct 2018; Accepted: 27 Nov 2018.

Edited by:

Zhe-Sheng Chen, St. John's University, United States

Reviewed by:

Xiaozhuo Liu, University at Buffalo, United States
Guannan Zhang, Perelman School of Medicine, University of Pennsylvania, United States  

Copyright: © 2018 Chen, Jia, Song and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Lei Zhang, Weifang Medical University, Weifang, China,