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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.00429

Use profile of Magnesium Sulfate in Anesthesia in Brazil

  • 1Universidade Federal Fluminense, Brazil
  • 2Brazilian National Cancer Institute (INCA), Brazil

Objectives: The use of magnesium sulfate in the perioperative period has several benefits, including analgesia, inhibition of the release of catecholamines and prevention of vasospasm. The aim of this survey was to provide an overview of the use of magnesium sulfate in anesthesia. Method: This was a prospective descriptive cross-sectional study. An online questionnaire was sent to 9869 Brazilian anesthesiologists and trainees. The questionnaire comprised closed questions mainly regarding the frequency, indications, adverse events and doses of magnesium sulfate used in anesthesia. Results: Of the 954 doctors who responded to the survey, 337 (35.32%) reported using magnesium sulfate in anesthesia. The most commonly cited indications for the use of magnesium sulfate in anesthesia were (n/%): postoperative analgesia (245/72.70%), reduction of anesthetic consumption (240 / 71.21%) and prevention and treatment of preeclampsia and seizures in eclampsia (220 / 65.28%). The most frequently reported adverse events were hypotension (187 / 55.48%), residual neuromuscular blockade (133/39.46%), hypermagnesemia (30/8.90%) and intravenous injection pain (26/7.71%). The intravenous doses of magnesium sulfate used in most general anesthesia inductions were between 30 and 40 mg.kg-1. Conclusions: Magnesium sulfate is an important adjuvant drug in the practice of anesthesia, with several clinical indications and a low incidence of adverse events when used at recommended doses.

Keywords: Anesthetics (MeSH), Analgesics, Magnesium Sulfate, Survey, adverse events

Received: 18 Jan 2019; Accepted: 04 Apr 2019.

Edited by:

Luciane C. Lopes, Universidade de Sorocaba, Brazil

Reviewed by:

Ludo Haazen, Self-employed
André O. Baldoni, Universidade Federal de São João del-Rei, Brazil  

Copyright: © 2019 Cavalcanti, Lima, Silva, Cruz Filho, Braga and Figueiredo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Ismar L. Cavalcanti, Universidade Federal Fluminense, Niterói, 24220-900, Rio de Janeiro, Brazil, ismarcavalcanti@gmail.com