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This article is part of the Research Topic

Applications of Nanobiotechnology in Pharmacology

Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.00447

Synergistic Effect of Retinoic Acid Polymeric Micelle and Prodrug for Pharmacodynamic Evaluation in Tumor Suppression

Yanhua Zhu1, Ning Ye1, Xinfeng Tang1, Malik Ihsanullah Khan1, Hongliang Liu2, Ning Shi2 and  Lifeng Hang3*
  • 1School of Life Science, University of Science and Technology of China, China
  • 2Shandong Liangfu Pharmaceutical Co., Ltd., China
  • 3University of Science and Technology of China, School of Life Science, University of Science and Technology of China, China

All-trans-retinoic acid (ATRA) is a very effective agent for inducing differentiation, inhibiting cell proliferation and reported as an anti-cancer agent. ATRA was successfully conjugated with pluronic-127 by esterification to enhance the ATRA anticancer effect. Pluronic-ATRA possessed high cytotoxicity and could efficiently reduce the IC50 value of ATRA against different breast cancer cells (4T1, EMT6, MDA-MB-231 and BT474). In combination with chemotherapy, pluronic-ATRA synergistically enhanced the cytotoxic effect of cisplatin (CDDP). Pluronic-ATRA combined with CDDP could effectively suppressed breast tumor in vivo. This study suggested the potential of pluronic ATRA, which can be used as an anticancer agent in combination therapy against solid tumor.

Keywords: all-trans-retinoic acid, Pluronic F127, Cisplatin, combination, breast cancer

Received: 26 Feb 2019; Accepted: 08 Apr 2019.

Edited by:

Jianxun Ding, Changchun Institute of Applied Chemistry (CAS), China

Reviewed by:

Ruinan Yang, Pharmaceutical Product Development (United States), United States
Youmei Bao, Yale University, United States
Xianzhu Yang, South China University of Technology, China  

Copyright: © 2019 Zhu, Ye, Tang, Khan, Liu, Shi and Hang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mr. Lifeng Hang, School of Life Science, University of Science and Technology of China, University of Science and Technology of China, Hefei, China,