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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.00503

Artocarpus tonkinensis protects mice against collagen-induced arthritis and decreases Th17 cell function

Sabrina Adorisio1,  Alessandra Fierabracci2,  Isabella Muscari1, Anna Marina Liberati1, Mario Calvitti1,  Lina Cossignani1,  Francesca Blasi1, Tran Duc Quan3,  Nguyen Thanh Tam3, Tran Van Sung3,  Carlo Riccardi1,  Trinh T. Thuy3 and  Domenico Delfino1*
  • 1University of Perugia, Italy
  • 2Bambino Gesù Children Hospital (IRCCS), Italy
  • 3Vietnam Academy of Science and Technology, Vietnam

Artocarpus tonkinensis is a tree that grows in north Vietnam whose leaf decoction is used as a traditional remedy by the Hmong ethnic group to treat arthritis and backache. Our study evaluated the decoction’s efficacy and mechanism of action in DBA/1J mice with collagen-induced arthritis (CIA). Mice treated with the decoction (At) either from the first collagen immunization or after CIA development experienced significantly less joint edema and inflammatory infiltration, whereas CIA-induced cartilage damage could only be prevented by early At treatment. Autoimmune gene expression profiles showed that Th17 cell-associated chemokine CCL20 and cytokines IL-6, IL-17, and IL-22 were strongly downregulated by At. Reduced expression of IL-2, IL-17, IL-22, and FasL in lymph node cells from At-treated mice was further confirmed by real-time PCR. The decoction also inhibited polarization of Th17 cells from CD4+ splenic T cells according to levels of IL-17 and RORC, a Th17 cell-specific transcription factor. Chromatographic analysis identified At’s major component as maesopsin-β-D-glucoside, which could inhibit in vitro differentiation of Th17 cells. The decoction significantly alleviated the signs and symptoms of CIA and inhibited the development and function of Th17 cells, highlighting its potent anti-inflammatory activity.

Keywords: Artocarpus tonkinensis, medicinal plants, Th17, Vietnam Traditional Medicine, Hmong ethnic minority, Arthritis, Autoimmunity

Received: 13 Dec 2018; Accepted: 23 Apr 2019.

Edited by:

Judit Hohmann, University of Szeged, Hungary

Reviewed by:

Ricardo M. Xavier, Federal University of Rio Grande do Sul, Brazil
Wei Wei, Anhui Medical University, China  

Copyright: © 2019 Adorisio, Fierabracci, Muscari, Liberati, Calvitti, Cossignani, Blasi, Quan, Tam, Sung, Riccardi, Thuy and Delfino. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Domenico Delfino, University of Perugia, Perugia, 06123, Umbria, Italy, domenico.delfino@unipg.it