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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.00582

Prediction of VEGF-C as a key target of pure total flavonoids from Citrus against NAFLD in mice via network pharmacology

Wei Hong1, Songsong Li1, Liyan Wu1, Beihui He1, Jianping Jiang1 and  Zhiyun Chen1*
  • 1First Affiliated Hospital, Zhejiang Chinese Medical University, China

Pure total flavonoids from Citrus (PTFC) effectively reduce the symptoms of non-alcoholic fatty liver disease (NAFLD). Our previous transcriptome analysis uncovered the alterations of important signaling pathways in the treatment of NAFLD with PTFC. However, the underlying core genes that might be targeted by PTFC, which play important roles in the progression of NALFD are yet to be identified. In this study, we predicted the vascular endothelial growth factor-C (VEGF-C) as potential key molecular target of PTFC against NAFLD via network pharmacology analysis. The network pharmacology approach presented here provided important clues for understanding the mechanisms of PTFC treatment in the development of NAFLD.

Keywords: Pure total flavonoids from Citrus, Non-alcoholic fatty liver disease, Vascular endothelial growth factor-C, Network Pharmacology, nonalcoholic steatohepatitis

Received: 22 Jan 2019; Accepted: 06 May 2019.

Edited by:

Raffaele Capasso, University of Naples Federico II, Italy

Reviewed by:

Guoxun Chen, The University of Tennessee, Knoxville, United States
Catherine Postic, Centre National de la Recherche Scientifique (CNRS), France  

Copyright: © 2019 Hong, Li, Wu, He, Jiang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Zhiyun Chen, First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310003, Zhejiang Province, China,