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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.00930

A systematic review exploring the anticancer activity and mechanisms of glucomannan

 Junyi Li1, Fei Sun2, Heng Fan1*, Haifeng Zhou2, Cong Huang3 and Jia Yang1
  • 1Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China
  • 2Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China
  • 3Integrative Traditional Chinese and Western Medicine, Tongji College of Huazhong University of Science and Technology, China

Glucomannan, long-recognized as the active ingredient of Traditional Chinese Medicinal Herb Konjac glucomannan, is a naturally-occurring polysaccharide existing in certain plant species and fungi. Due to its special property to also serve as a dietary supplement, glucomannan has been widely applied in clinic to lower body weight, circulation cholesterol level and to treat constipation, diabetes and arterial sclerosis. Besides the regulatory role engaged with gastroenterological and metabolic syndrome, recently, its therapeutic effect and the underlying mechanisms in treating cancerous diseases have been appreciated by mounting researches. The present review aims to emphasize the multifaceted aspects of how glucomannan exerts its anti-tumor function.

Keywords: Apoptosis, Anti-tumor effect, polysaccharide, Glucomannan, Drug-carrier

Received: 11 Jun 2019; Accepted: 22 Jul 2019.

Edited by:

Jiangjiang Qin, Zhejiang Chinese Medical University, China

Reviewed by:

Qi Zeng, Xidian University, China
QIANG WANG, Nanjing Drum Tower Hospital, China  

Copyright: © 2019 Li, Sun, Fan, Zhou, Huang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Heng Fan, Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, fanheng009@aliyun.com