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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.00952

A pharmacological overview of alpinumisoflavone, a natural prenylated isoflavonoid

  • 1Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Cameroon
  • 2Department of Animal Biology, Faculty of Science, University of Dschang, Cameroon
  • 3University of Maroua, Cameroon
  • 4Department of Pharmacognosy, University of Vienna, Austria

Over the last decade, several studies demonstrated that prenylation of flavonoids enhances various biological activities as compared to the respective non-prenylated compounds. In line with this, the natural prenylated isoflavonoid alpinumisoflavone (AIF) has been explored for a number of biological and pharmacological effects (therapeutic potential). In this review, we attempt to summarize the current information and health-promoting properties of AIF. Reported data evidenced that AIF has a multi-therapeutic potential with anti-osteoporotic, anti-oxidant and anti-inflammatory, anti-microbial, anti-cancer, estrogenic and anti-estrogenic, anti-diabetic and neuroprotective properties. However, research on these aspects of AIF is not sufficient and somehow need to be reevaluated using more appropriate methods and methodology. Further series of studies are therefore needed to enrich the knowledge of these pharmacological effects. Overall, despite the drawbacks of studies recorded, AIF exhibits a potential as drug candidate.

Keywords: Alpinumisoflavone, Therapeutic potential, natural product, prenylated isoflavonoid, structure-activity relationship

Received: 25 Feb 2019; Accepted: 26 Jul 2019.

Copyright: © 2019 Ateba, MVONDO, Djiogue, Zingue, Krenn and Njamen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: PhD. Sylvin B. Ateba, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Yaounde, Cameroon,